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• W2100024508 abstract "Background: Apoptosis and cell proliferation in patients with adenocarcinoma of the lung have not been well described with relation to fine-needle aspiration biopsies (FNABs). To investigate the contribution of apoptosis to the growth of adenocarcinoma of the lung, both apoptosis and cell proliferation were analysed for correlation with the grade of the tumor. Patients and Methods: Fifty tumors from 50 patients with adenocarcinoma of the lung were studied. Twelve tumors were well-differentiated, 22 were moderately differentiated and 16 were poorly differentiated. The detection of DNA fragments in situ using the terminal deoxyribonucleotidyl transferase - mediated dUTP- digoxigenin nick-end labeling (TUNEL) assay was applied to investigate active cell death (apoptosis) and the MIB-1 antigen was used to investigate cell proliferation. Results: The TUNEL indices were 0.55±0.09, 0.90±0.33 and 3.1±0.99 in well-, moderately and poorly differentiated adenocarcinoma of the lung respectively. The MIB-1 antigen labeling indices were 7.1±0.12, 14.3±3.5 and 28.7±6.9, respectively, in the same order of tumor differentiation. The differences in both TUNEL and MIB-1 labeling indices were significant between well-, moderately and poorly differentiated adenocarcinoma of the lung and a positive correlation was found between the TUNEL indices and the MIB-1 indices. Conclusion: Apoptosis (cell death) and cell proliferation increases as the grade of differentiation decreases in adenocarcinoma of the lung, suggesting a rapid turn over of the tumor cells in tumors with a lower grade of differentiation. Adenocarcinoma (AC) of the lung is a malignant tumor with poor prognosis. To improve the prognosis, it is important to establish biological markers, other than tumor, node, and metastasis factors, that determine prognosis and response toward a particular treatment (1). Apoptosis, a mode of cell death clearly distinct from necrosis, is a physiological phenomenon that occurs spontaneously in the process of normal tissue growth (2). Apoptosis has also been shown to be closely associated with malignant tumors and abnormality in the process of apoptosis promotes malignant transformation and leads to tumor proliferation. The balance between apoptosis and cell proliferation may play an important role in carcinogenesis. Most of the previously reported results suggest that apoptosis is a form of cell death as a secondary result of active cell division and proliferation (3). It is particularly important when discussing tumor progression to consider balance of both cell death and cell proliferation because an argument based on only one of these factors may lead to an incorrect or confusing conclusion. Nevertheless, attention has been focused in preceding investigations exclusively on whether the fraction of either apoptotic or proliferating cells is high or low in a particular malignant tissue. In the present study, we conducted a detailed investigation on the balance of apoptosis and cell proliferation on fine-needle aspiration biopsy (FNABs) in patients with lung AC correlated with tumor grade in order to demonstrate that apoptosis and cell proliferation have a biologic significance as prognostic factors." @default.
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• W2100024508 date "2010-09-01" @default.
• W2100024508 modified "2023-09-26" @default.
• W2100024508 title "Apoptosis and Cell Proliferation Correlated with Tumor Grade in Patients with Lung Adenocarcinoma" @default.
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