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• W2100026582 abstract "Bursicon is an insect neuropeptide hormone that is secreted from the central nervous system into the hemolymph and initiates cuticle tanning. The receptor for bursicon is encoded by the rickets (rk) gene and belongs to the G protein-coupled receptor (GPCR) superfamily. The bursicon and its receptor regulate cuticle tanning as well as wing expansion after adult eclosion. However, the molecular action of bursicon signaling remains unclear. We utilized RNA interference (RNAi) and microarray to study the function of the bursicon receptor (Tcrk) in the model insect, Tribolium castaneum. The data included here showed that in addition to cuticle tanning and wing expansion reported previously, Tcrk is also required for development and expansion of integumentary structures and adult eclosion. Using custom microarrays, we identified 24 genes that are differentially expressed between Tcrk RNAi and control insects. Knockdown in the expression of one of these genes, TC004091, resulted in the arrest of adult eclosion. Identification of genes that are involved in bursicon receptor mediated biological processes will provide tools for future studies on mechanisms of bursicon action." @default.
• W2100026582 created "2016-06-24" @default.
• W2100026582 creator A5013800323 @default.
• W2100026582 creator A5087680483 @default.
• W2100026582 date "2010-08-01" @default.
• W2100026582 modified "2023-10-12" @default.
• W2100026582 title "Functional characterization of bursicon receptor and genome-wide analysis for identification of genes affected by bursicon receptor RNAi" @default.
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• W2100026582 doi "https://doi.org/10.1016/j.ydbio.2010.05.003" @default.
• W2100026582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909337" @default.
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