FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100026885> ?p ?o ?g. }

• W2100026885 endingPage "1256" @default.
• W2100026885 startingPage "1243" @default.
• W2100026885 abstract "OBJECTIVE: To review the risk of HIV infection following occupational exposure, the theoretical basis for chemoprophylaxis, investigative experience with chemoprophylaxis in animals and humans, and the economic aspects of postexposure chemoprophylaxis. DATA SOURCES: English-language articles and conference proceedings pertaining to the risk of occupational HIV infection and to postexposure chemoprophylaxis. STUDY SELECTION: Studies evaluating chemoprophylaxis of HIV infection following occupational exposure were selected for review. Abstracts reporting ongoing clinical trials were also included. DATA EXTRACTION: In vitro studies are discussed to provide the immunologic rationale for chemoprophylaxis. Animal studies examining the efficacy of chemoprophylaxis in preventing non-HIV retroviral infection are reviewed, and their applicability to human HIV infection is critically evaluated. Human studies and case reports describing attempts at chemoprophylaxis of HIV infection following occupational exposure are discussed. DATA SYNTHESIS: Chemoprophylaxis of HIV infection following occupational exposure has focused on the use of zidovudine (ZDV) because it was previously the only antiretroviral agent approved for treating HIV infection. Animal models of retroviral infection provide conflicting data regarding the efficacy of ZDV chemoprophylaxis, and there are important questions about the applicability of animal data to human HIV infection because of differences in natural histories of non-HIV retroviral infections, inoculum size, dosing of ZDV, and routes of infection. Human surveillance studies are thus far inadequate to determine the efficacy of ZDV prophylaxis because of the very low HIV seroconversion rates following occupational exposure. ZDV is well tolerated during short-term administration in people without HIV infection, but long-term safety is unknown. In addition, the true cost-benefit ratio of ZDV chemoprophylaxis is uncertain. CONCLUSIONS: Current data from in vitro, animal, and human studies are inadequate to define the appropriate role of ZDV in preventing HIV infection following occupational exposure. Limited toxicity data and the high cost of treatment must be weighed against the theoretical benefits of ZDV use in this setting. The decision to employ ZDV for postexposure prophylaxis must ultimately be based on existing institutional policies, the attitude of the responsible physician regarding such practice, and/or the desires of the exposed healthcare worker after being properly informed of potential risks and benefits." @default.
• W2100026885 created "2016-06-24" @default.
• W2100026885 creator A5082697782 @default.
• W2100026885 date "1993-10-01" @default.
• W2100026885 modified "2023-09-26" @default.
• W2100026885 title "Prophylaxis of HIV Infection following Occupational Exposure" @default.
• W2100026885 cites W1476609589 @default.
• W2100026885 cites W1894456574 @default.
• W2100026885 cites W1965995080 @default.
• W2100026885 cites W1969178024 @default.
• W2100026885 cites W1973926449 @default.
• W2100026885 cites W1975511178 @default.
• W2100026885 cites W1979989842 @default.
• W2100026885 cites W1980052042 @default.
• W2100026885 cites W1981890703 @default.
• W2100026885 cites W1983910018 @default.
• W2100026885 cites W1984847573 @default.
• W2100026885 cites W1985774427 @default.
• W2100026885 cites W1988053484 @default.
• W2100026885 cites W1991053746 @default.
• W2100026885 cites W1991144585 @default.
• W2100026885 cites W1991377066 @default.
• W2100026885 cites W1993355882 @default.
• W2100026885 cites W2000625719 @default.
• W2100026885 cites W2003100693 @default.
• W2100026885 cites W2006597943 @default.
• W2100026885 cites W2009226722 @default.
• W2100026885 cites W2016395787 @default.
• W2100026885 cites W2016645880 @default.
• W2100026885 cites W2018643676 @default.
• W2100026885 cites W2020684681 @default.
• W2100026885 cites W2020702723 @default.
• W2100026885 cites W2026990241 @default.
• W2100026885 cites W2030435996 @default.
• W2100026885 cites W2032356564 @default.
• W2100026885 cites W2036282594 @default.
• W2100026885 cites W2045574954 @default.
• W2100026885 cites W2046390563 @default.
• W2100026885 cites W2046699230 @default.
• W2100026885 cites W2047147448 @default.
• W2100026885 cites W2054270892 @default.
• W2100026885 cites W2054620412 @default.
• W2100026885 cites W2054724326 @default.
• W2100026885 cites W2060712086 @default.
• W2100026885 cites W2063630358 @default.
• W2100026885 cites W2064078310 @default.
• W2100026885 cites W2066121768 @default.
• W2100026885 cites W2068444298 @default.
• W2100026885 cites W2073511157 @default.
• W2100026885 cites W2075517475 @default.
• W2100026885 cites W2080706877 @default.
• W2100026885 cites W2082814103 @default.
• W2100026885 cites W2084207888 @default.
• W2100026885 cites W2086462809 @default.
• W2100026885 cites W2086668198 @default.
• W2100026885 cites W2087113983 @default.
• W2100026885 cites W2087126403 @default.
• W2100026885 cites W2092587037 @default.
• W2100026885 cites W2108385781 @default.
• W2100026885 cites W2109694248 @default.
• W2100026885 cites W2116464980 @default.
• W2100026885 cites W2116496621 @default.
• W2100026885 cites W2128175070 @default.
• W2100026885 cites W2132936712 @default.
• W2100026885 cites W2140537541 @default.
• W2100026885 cites W2142566043 @default.
• W2100026885 cites W2154901034 @default.
• W2100026885 cites W2163237181 @default.
• W2100026885 cites W2168509098 @default.
• W2100026885 cites W2288043609 @default.
• W2100026885 cites W2320148944 @default.
• W2100026885 cites W2325555859 @default.
• W2100026885 cites W2331886032 @default.
• W2100026885 cites W2333399282 @default.
• W2100026885 cites W2337467976 @default.
• W2100026885 cites W2339910025 @default.
• W2100026885 cites W2408178726 @default.
• W2100026885 cites W24167757 @default.
• W2100026885 cites W4245565153 @default.
• W2100026885 doi "https://doi.org/10.1177/106002809302701015" @default.
• W2100026885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8251695" @default.
• W2100026885 hasPublicationYear "1993" @default.
• W2100026885 type Work @default.
• W2100026885 sameAs 2100026885 @default.
• W2100026885 citedByCount "4" @default.
• W2100026885 crossrefType "journal-article" @default.
• W2100026885 hasAuthorship W2100026885A5082697782 @default.
• W2100026885 hasConcept C126322002 @default.
• W2100026885 hasConcept C203014093 @default.
• W2100026885 hasConcept C2776688490 @default.
• W2100026885 hasConcept C2777288759 @default.
• W2100026885 hasConcept C2778283251 @default.
• W2100026885 hasConcept C2780216070 @default.
• W2100026885 hasConcept C2780727368 @default.
• W2100026885 hasConcept C3013748606 @default.
• W2100026885 hasConcept C535046627 @default.
• W2100026885 hasConcept C71924100 @default.
• W2100026885 hasConceptScore W2100026885C126322002 @default.

• next