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- W2100027531 endingPage "636" @default.
- W2100027531 startingPage "623" @default.
- W2100027531 abstract "Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT1A) subtype, in both disorders. In this review, we examine the function of 5-HT1A receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT1A receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors. It is difficult to unambiguously distinguish the effects of different populations of the 5-HT1A receptors with traditional genetic animal models and pharmacological approaches. However, with the advent of novel genetic systems and subpopulation-selective pharmacological agents, direct evidence for the distinct roles of these populations in governing emotion-related behavior is emerging. There is strong and growing evidence for a functional dissociation between auto- and heteroreceptor populations in mediating anxiety and depressive-like behaviors, respectively. Furthermore, while it is well established that 5-HT1A receptors act developmentally to establish normal anxiety-like behaviors, the developmental role of 5-HT1A heteroreceptors is less clear, and the specific mechanisms underlying the developmental role of each subpopulation are likely to be key elements determining mood control in adult subjects." @default.
- W2100027531 created "2016-06-24" @default.
- W2100027531 creator A5045801598 @default.
- W2100027531 creator A5050072689 @default.
- W2100027531 creator A5061898956 @default.
- W2100027531 date "2013-12-12" @default.
- W2100027531 modified "2023-09-27" @default.
- W2100027531 title "P5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function" @default.
- W2100027531 cites W107475310 @default.
- W2100027531 cites W1523136835 @default.
- W2100027531 cites W1523202621 @default.
- W2100027531 cites W1543276710 @default.
- W2100027531 cites W1710423957 @default.
- W2100027531 cites W1751417589 @default.
- W2100027531 cites W1928086561 @default.
- W2100027531 cites W1929691281 @default.
- W2100027531 cites W1931238753 @default.
- W2100027531 cites W194835070 @default.
- W2100027531 cites W1963690073 @default.
- W2100027531 cites W1966173192 @default.
- W2100027531 cites W1970840237 @default.
- W2100027531 cites W1970863205 @default.
- W2100027531 cites W1972663341 @default.
- W2100027531 cites W1973054854 @default.
- W2100027531 cites W1974420087 @default.
- W2100027531 cites W1981413819 @default.
- W2100027531 cites W1982313492 @default.
- W2100027531 cites W1983230599 @default.
- W2100027531 cites W1984168485 @default.
- W2100027531 cites W1984815383 @default.
- W2100027531 cites W1985445017 @default.
- W2100027531 cites W1986146402 @default.
- W2100027531 cites W1987299915 @default.
- W2100027531 cites W1987465746 @default.
- W2100027531 cites W1987837679 @default.
- W2100027531 cites W1988308733 @default.
- W2100027531 cites W1988959458 @default.
- W2100027531 cites W1990454576 @default.
- W2100027531 cites W1991155688 @default.
- W2100027531 cites W1994164430 @default.
- W2100027531 cites W1994702289 @default.
- W2100027531 cites W1995780552 @default.
- W2100027531 cites W1996447644 @default.
- W2100027531 cites W1996694057 @default.
- W2100027531 cites W1997357796 @default.
- W2100027531 cites W2000247455 @default.
- W2100027531 cites W2001023145 @default.
- W2100027531 cites W2001044475 @default.
- W2100027531 cites W2004772633 @default.
- W2100027531 cites W2006460397 @default.
- W2100027531 cites W2007612689 @default.
- W2100027531 cites W2007890963 @default.
- W2100027531 cites W2008743836 @default.
- W2100027531 cites W2008980764 @default.
- W2100027531 cites W2010691586 @default.
- W2100027531 cites W2010764823 @default.
- W2100027531 cites W2012102163 @default.
- W2100027531 cites W2014184776 @default.
- W2100027531 cites W2015536698 @default.
- W2100027531 cites W2016983964 @default.
- W2100027531 cites W2017727557 @default.
- W2100027531 cites W2018085592 @default.
- W2100027531 cites W2020016243 @default.
- W2100027531 cites W2022468859 @default.
- W2100027531 cites W2022816995 @default.
- W2100027531 cites W2023043984 @default.
- W2100027531 cites W2023118385 @default.
- W2100027531 cites W2023229299 @default.
- W2100027531 cites W2023854352 @default.
- W2100027531 cites W2024295917 @default.
- W2100027531 cites W2024379900 @default.
- W2100027531 cites W2027062631 @default.
- W2100027531 cites W2028524283 @default.
- W2100027531 cites W2028727536 @default.
- W2100027531 cites W2028977103 @default.
- W2100027531 cites W2028980996 @default.
- W2100027531 cites W2029003010 @default.
- W2100027531 cites W2031156732 @default.
- W2100027531 cites W2031415599 @default.
- W2100027531 cites W2031882709 @default.
- W2100027531 cites W2038771513 @default.
- W2100027531 cites W2039200237 @default.
- W2100027531 cites W2040223618 @default.
- W2100027531 cites W2040779842 @default.
- W2100027531 cites W2045741140 @default.
- W2100027531 cites W2047200908 @default.
- W2100027531 cites W2049563161 @default.
- W2100027531 cites W2050087878 @default.
- W2100027531 cites W2050932570 @default.
- W2100027531 cites W2051423370 @default.
- W2100027531 cites W2051670734 @default.
- W2100027531 cites W2052213011 @default.
- W2100027531 cites W2052519442 @default.
- W2100027531 cites W2054240764 @default.
- W2100027531 cites W2054263853 @default.
- W2100027531 cites W2054695075 @default.
- W2100027531 cites W2057542824 @default.
- W2100027531 cites W2057569019 @default.