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• W2100028283 abstract "Voltage-gated L-type Ca2+ channels from cardiac (α1C) and skeletal (α1S) muscle differ from one another in ion selectivity and permeation properties, including unitary conductance. In 110 mM Ba2+, unitary conductance of α1S is approximately half that of α1C. As a step toward understanding the mechanism of rapid ion flux through these highly selective ion channels, we used chimeras constructed between α1C and α1S to identify structural features responsible for the difference in conductance. Combined replacement of the four pore-lining P-loops in α1C with P-loops from α1S reduced unitary conductance to a value intermediate between those of the two parent channels. Combined replacement of four larger regions that include sequences flanking the P-loops (S5 and S6 segments along with the P-loop-containing linker between these segments (S5–6)) conferred α1S-like conductance on α1C. Likewise, substitution of the four S5–6 regions of α1C into α1S conferred α1C-like conductance on α1S. These results indicate that, comparing α1C with α1S, the differences in structure that are responsible for the difference in ion conduction are housed within the S5–6 regions. Moreover, the pattern of unitary conductance values obtained for chimeras in which a single P-loop or single S5–6 region was replaced suggest a concerted action of pore-lining regions in the control of ion conduction." @default.
• W2100028283 created "2016-06-24" @default.
• W2100028283 creator A5000412160 @default.
• W2100028283 creator A5026714090 @default.
• W2100028283 date "2003-03-01" @default.
• W2100028283 modified "2023-09-30" @default.
• W2100028283 title "Control of Ion Conduction in L-type Ca2+ Channels by the Concerted Action of S5–6 Regions" @default.
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• W2100028283 doi "https://doi.org/10.1016/s0006-3495(03)74979-0" @default.
• W2100028283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1302740" @default.
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