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• W2100028609 endingPage "121" @default.
• W2100028609 startingPage "108" @default.
• W2100028609 abstract "Resolvases and DNA invertases catalyse site-specific recombination by a concerted cut-and-religate mechanism. Topological data strongly suggest a rotational movement of the DNA half-sites during recombination: in an iterative mode of reaction, after cleavage of all four strands of the two recombining sites, the recombinase-linked half-sites seem to rotate through multiple steps of 180 degrees prior to final religation. However, current structural data provide no clear support for the postulated corresponding rotation of enzyme subunits within an active tetramer. A key issue is whether repetition of apparent 180 degrees rotation steps requires rejoining of the DNA strands and resetting of the catalytic machinery, or if multiple rotation steps can take place in the fully cleaved intermediate. We present evidence that a resolvase-catalysed DNA knotting reaction, brought about by apparent 360 degrees rotation, can proceed without rejoining of the DNA strands in the recombinant (180 degrees rotation) configuration. This behaviour is not compatible with a mechanism requiring a fixed arrangement of the catalytic subunits, and strongly suggests that recombination is coupled to disruption of the dimer interface between two subunits bound at each crossover site. We also show that an artificial supercoiled plasmid containing two res sites, with a single mismatched base-pair in one of the crossover sites, is a substrate for suicidal reactions in which resolvase remains covalently linked to two half-sites." @default.
• W2100028609 created "2016-06-24" @default.
• W2100028609 creator A5011692701 @default.
• W2100028609 creator A5027175759 @default.
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• W2100028609 date "1997-02-01" @default.
• W2100028609 modified "2023-09-25" @default.
• W2100028609 title "Tn3 resolvase catalyses multiple recombination events without intermediate rejoining of DNA ends 1 1 Edited by J. Karn" @default.
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• W2100028609 doi "https://doi.org/10.1006/jmbi.1996.0765" @default.
• W2100028609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9054974" @default.
• W2100028609 hasPublicationYear "1997" @default.
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