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- W2100028938 abstract "Hepatitis C virus (HCV) chronic infection is recognized as the major cause of mixed cryoglobulinemia (MC). Its persistence represents a continuous stimulus for host immune system with production of circulating immune complexes (ICs), one-third of them with cryoprecipitate property. Several factors contribute to the biological activities of ICs, many of which are not completely known. Among them, complement factors play a crucial role in the cold-insoluble ICs-mediated vasculitis, involving primarily small blood vessels in different tissues including skin, kidney, peripheral, and central nervous system. Liver represents the major target of HCV infection with inflammatory infiltrates, resembling secondary lymphoid follicles. Cytokine like CXCL13 contribute to B-cell homing in intraportal lymphoid aggregates, in which B-cell clonal selection may arise. B-cell clonal expansion starts as an antigen-driven event and expands towards indolent and malignant B-cell proliferation. Occurrence of intrahepatic B-cell clonalities correlates with extrahepatic clinical manifestations of HCV infection. In this context, cryoglobulinemic patients should be considered a peculiar HCV-infected population that needs a clinical multidisciplinary approach and more articulated therapeutic measures." @default.
- W2100028938 created "2016-06-24" @default.
- W2100028938 creator A5011114134 @default.
- W2100028938 creator A5042277842 @default.
- W2100028938 creator A5055283017 @default.
- W2100028938 creator A5066185290 @default.
- W2100028938 date "2012-01-01" @default.
- W2100028938 modified "2023-10-08" @default.
- W2100028938 title "Hepatitis C Virus Infection and Mixed Cryoglobulinemia" @default.
- W2100028938 cites W1548460291 @default.
- W2100028938 cites W1552189228 @default.
- W2100028938 cites W1906411012 @default.
- W2100028938 cites W1965128383 @default.
- W2100028938 cites W1965670111 @default.
- W2100028938 cites W1969334674 @default.
- W2100028938 cites W1972037938 @default.
- W2100028938 cites W1974813074 @default.
- W2100028938 cites W1981190826 @default.
- W2100028938 cites W1982304294 @default.
- W2100028938 cites W1982644308 @default.
- W2100028938 cites W1983660597 @default.
- W2100028938 cites W1985089150 @default.
- W2100028938 cites W1986505810 @default.
- W2100028938 cites W1988458629 @default.
- W2100028938 cites W1992004393 @default.
- W2100028938 cites W1992735658 @default.
- W2100028938 cites W1992777337 @default.
- W2100028938 cites W1995744706 @default.
- W2100028938 cites W1995901131 @default.
- W2100028938 cites W1996497815 @default.
- W2100028938 cites W1996869017 @default.
- W2100028938 cites W2003036666 @default.
- W2100028938 cites W2005759537 @default.
- W2100028938 cites W2007974735 @default.
- W2100028938 cites W2010302636 @default.
- W2100028938 cites W2015489330 @default.
- W2100028938 cites W2016242396 @default.
- W2100028938 cites W2019985783 @default.
- W2100028938 cites W2022993300 @default.
- W2100028938 cites W2025840862 @default.
- W2100028938 cites W2028453745 @default.
- W2100028938 cites W2030186927 @default.
- W2100028938 cites W2038832956 @default.
- W2100028938 cites W2038901073 @default.
- W2100028938 cites W2039937105 @default.
- W2100028938 cites W2042707268 @default.
- W2100028938 cites W2044713055 @default.
- W2100028938 cites W2046757081 @default.
- W2100028938 cites W2046900942 @default.
- W2100028938 cites W2047208492 @default.
- W2100028938 cites W2047619297 @default.
- W2100028938 cites W2050402586 @default.
- W2100028938 cites W2053886781 @default.
- W2100028938 cites W2054518275 @default.
- W2100028938 cites W2057940890 @default.
- W2100028938 cites W2057963135 @default.
- W2100028938 cites W2060706585 @default.
- W2100028938 cites W2063150581 @default.
- W2100028938 cites W2063760041 @default.
- W2100028938 cites W2066036969 @default.
- W2100028938 cites W2066931983 @default.
- W2100028938 cites W2071136569 @default.
- W2100028938 cites W2071288799 @default.
- W2100028938 cites W2072092596 @default.
- W2100028938 cites W2072681498 @default.
- W2100028938 cites W2075032135 @default.
- W2100028938 cites W2076466820 @default.
- W2100028938 cites W2077138984 @default.
- W2100028938 cites W2077477264 @default.
- W2100028938 cites W2077515082 @default.
- W2100028938 cites W2085106134 @default.
- W2100028938 cites W2090978265 @default.
- W2100028938 cites W2096779842 @default.
- W2100028938 cites W2100227035 @default.
- W2100028938 cites W2106132583 @default.
- W2100028938 cites W2108302171 @default.
- W2100028938 cites W2110992334 @default.
- W2100028938 cites W2112346826 @default.
- W2100028938 cites W2114123652 @default.
- W2100028938 cites W2114517845 @default.
- W2100028938 cites W2124151787 @default.
- W2100028938 cites W2124528668 @default.
- W2100028938 cites W2126844156 @default.
- W2100028938 cites W2126960075 @default.
- W2100028938 cites W2129743974 @default.
- W2100028938 cites W2140850442 @default.
- W2100028938 cites W2142337801 @default.
- W2100028938 cites W2143560324 @default.
- W2100028938 cites W2147997906 @default.
- W2100028938 cites W2148740102 @default.
- W2100028938 cites W2153346747 @default.
- W2100028938 cites W2157551016 @default.
- W2100028938 cites W2158977173 @default.
- W2100028938 cites W2159627145 @default.
- W2100028938 cites W2159864982 @default.
- W2100028938 cites W2165542457 @default.
- W2100028938 cites W2166580185 @default.
- W2100028938 cites W2324507396 @default.