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- W2100029896 abstract "Unlike most drugs the half-life of salicylates in the serum of human subjects increases as its concentration increases; this observation was confirmed in nine hospitalized patients with rheumatoid arthritis who received the same weight-adjusted dose of aspirin. They showed marked variations in the maximum salicylate concentrations attained. A relatively small increase in dose resulted in a large increase in serum level. Therefore, optimum intensive salicylate therapy can be achieved only by individualizing the dose of aspirin." @default.
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- W2100029896 date "1971-07-01" @default.
- W2100029896 modified "2023-10-18" @default.
- W2100029896 title "Variations of serum concentrations and half-life of salicylate in patients with rheumatoid arthritis" @default.
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- W2100029896 doi "https://doi.org/10.1002/art.1780140412" @default.
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