FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100031177> ?p ?o ?g. }

• W2100031177 abstract "A previous systematic review reported that topical NSAIDs were effective in relieving pain in acute conditions like sprains and strains, with differences between individual drugs for efficacy. More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review.Studies were identified by searching electronic databases and writing to manufacturers. We selected randomised double blind trials comparing topical NSAID with either placebo or another active treatment in adults with acute pain, and extracted dichotomous information approximating to a 50% reduction in pain at one week, together with details of adverse events and withdrawals. Relative benefit and number-needed-to-treat (NNT), and relative risk and number-needed-to-harm (NNH) were calculated, with sensitivity analyses where appropriate to investigate differences between individual drugs and aspects of trial design.Twenty-six double blind placebo controlled trials had information from 2,853 patients for evaluation of efficacy. Topical NSAID was significantly better than placebo in 19 of the 26 trials, with a pooled relative benefit of 1.6 (95% confidence interval 1.4 to 1.7), and NNT of 3.8 (95% confidence interval 3.4 to 4.4) compared with placebo for the outcome of half pain relief at seven days. Results were not affected by outcome reported, or condition treated, but smaller trials yielded a larger estimate of efficacy. Indirect comparisons of individual topical NSAIDs showed that ketoprofen was significantly better than all other topical NSAIDs, while indomethacin was barely distinguished from placebo. Three trials, with 433 patients, compared topical with oral NSAID (two trials compared the same drug, one compared different drugs) and found no difference in efficacy. Local adverse events, systemic adverse events, or withdrawals due to an adverse event were rare, and no different between topical NSAID and placebo.Topical NSAIDs were effective and safe in treating acute painful conditions for one week." @default.
• W2100031177 created "2016-06-24" @default.
• W2100031177 creator A5049385540 @default.
• W2100031177 creator A5049570304 @default.
• W2100031177 creator A5063980426 @default.
• W2100031177 creator A5066128384 @default.
• W2100031177 creator A5077191679 @default.
• W2100031177 date "2004-05-17" @default.
• W2100031177 modified "2023-10-12" @default.
• W2100031177 title "Topical NSAIDs for acute pain: a meta-analysis" @default.
• W2100031177 cites W124212663 @default.
• W2100031177 cites W1480729244 @default.
• W2100031177 cites W1489868193 @default.
• W2100031177 cites W151571389 @default.
• W2100031177 cites W1796956329 @default.
• W2100031177 cites W1891633120 @default.
• W2100031177 cites W190432982 @default.
• W2100031177 cites W1977093181 @default.
• W2100031177 cites W1980089953 @default.
• W2100031177 cites W1984445114 @default.
• W2100031177 cites W1986215651 @default.
• W2100031177 cites W2000442546 @default.
• W2100031177 cites W2031268164 @default.
• W2100031177 cites W2038693293 @default.
• W2100031177 cites W2040766195 @default.
• W2100031177 cites W2041221488 @default.
• W2100031177 cites W2047577726 @default.
• W2100031177 cites W2052427292 @default.
• W2100031177 cites W2071267251 @default.
• W2100031177 cites W2080724564 @default.
• W2100031177 cites W2081320515 @default.
• W2100031177 cites W2090362854 @default.
• W2100031177 cites W2092233783 @default.
• W2100031177 cites W2099196040 @default.
• W2100031177 cites W2110759336 @default.
• W2100031177 cites W2111149452 @default.
• W2100031177 cites W2115461417 @default.
• W2100031177 cites W2116446898 @default.
• W2100031177 cites W2124279634 @default.
• W2100031177 cites W2134338262 @default.
• W2100031177 cites W2144504916 @default.
• W2100031177 cites W2185982339 @default.
• W2100031177 cites W2254126555 @default.
• W2100031177 cites W2328026726 @default.
• W2100031177 cites W23630014 @default.
• W2100031177 cites W2412261023 @default.
• W2100031177 cites W2417900732 @default.
• W2100031177 cites W2460848478 @default.
• W2100031177 cites W4214731748 @default.
• W2100031177 cites W4233954896 @default.
• W2100031177 cites W4239539738 @default.
• W2100031177 cites W4240157642 @default.
• W2100031177 cites W55818572 @default.
• W2100031177 cites W58019836 @default.
• W2100031177 cites W93604404 @default.
• W2100031177 cites W2595437246 @default.
• W2100031177 doi "https://doi.org/10.1186/1471-2296-5-10" @default.
• W2100031177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/420463" @default.
• W2100031177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15147585" @default.
• W2100031177 hasPublicationYear "2004" @default.
• W2100031177 type Work @default.
• W2100031177 sameAs 2100031177 @default.
• W2100031177 citedByCount "114" @default.
• W2100031177 countsByYear W21000311772012 @default.
• W2100031177 countsByYear W21000311772013 @default.
• W2100031177 countsByYear W21000311772014 @default.
• W2100031177 countsByYear W21000311772015 @default.
• W2100031177 countsByYear W21000311772016 @default.
• W2100031177 countsByYear W21000311772017 @default.
• W2100031177 countsByYear W21000311772018 @default.
• W2100031177 countsByYear W21000311772019 @default.
• W2100031177 countsByYear W21000311772020 @default.
• W2100031177 countsByYear W21000311772021 @default.
• W2100031177 countsByYear W21000311772022 @default.
• W2100031177 countsByYear W21000311772023 @default.
• W2100031177 crossrefType "journal-article" @default.
• W2100031177 hasAuthorship W2100031177A5049385540 @default.
• W2100031177 hasAuthorship W2100031177A5049570304 @default.
• W2100031177 hasAuthorship W2100031177A5063980426 @default.
• W2100031177 hasAuthorship W2100031177A5066128384 @default.
• W2100031177 hasAuthorship W2100031177A5077191679 @default.
• W2100031177 hasBestOaLocation W21000311771 @default.
• W2100031177 hasConcept C126322002 @default.
• W2100031177 hasConcept C142454548 @default.
• W2100031177 hasConcept C142724271 @default.
• W2100031177 hasConcept C168563851 @default.
• W2100031177 hasConcept C1862650 @default.
• W2100031177 hasConcept C197934379 @default.
• W2100031177 hasConcept C204787440 @default.
• W2100031177 hasConcept C27081682 @default.
• W2100031177 hasConcept C2780744026 @default.
• W2100031177 hasConcept C42219234 @default.
• W2100031177 hasConcept C44249647 @default.
• W2100031177 hasConcept C535046627 @default.
• W2100031177 hasConcept C67774102 @default.
• W2100031177 hasConcept C71924100 @default.
• W2100031177 hasConcept C82789193 @default.
• W2100031177 hasConcept C95190672 @default.
• W2100031177 hasConcept C98274493 @default.
• W2100031177 hasConceptScore W2100031177C126322002 @default.

• next