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- W2100031903 abstract "The extracellular matrix is synthesized predominantly by fibroblasts and gives tissue its structural integrity. It is remodeled by ultraviolet radiation via the increased expression/activities of matrix metalloproteinases (MMP) and inhibition of the tissue inhibitors of matrix metalloproteinases (TIMP). On the other hand, transforming growth factor-β (TGF-β) stimulates extracellular matrix deposition. The hypothesis of the research was the counteraction of UV radiation effects on fibroblasts by a TGF-β inducing agent (AT). Non-irradiated and UVB radiated fibroblasts were exposed to AT and examined for MMP-1 promoter activity, and expression of MMP-2, TIMP-1, and TIMP-2. AT inhibited MMP-1 promoter activity and dramatically stimulated MMP-2 expression; its effects were antagonized by UV radiation. The dramatic stimulation of TIMPs by AT predominated in non-irradiated and UV irradiated fibroblasts. TGF-β induction in fibroblasts is therefore an effective strategy to counteract UV radiation induced damage to the extracellular matrix, particularly through the induction of TIMPs." @default.
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- W2100031903 date "2009-03-01" @default.
- W2100031903 modified "2023-10-18" @default.
- W2100031903 title "Inhibition of Ultraviolet Radiation Mediated Extracellular Matrix Remodeling in Fibroblasts by Transforming Growth Factor-β" @default.
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- W2100031903 doi "https://doi.org/10.1893/011.080.0104" @default.
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