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• W2100032318 abstract "A sensitive reversed-phase high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of imatinib, a tyrosine kinase inhibitor, and its main metabolite N-desmethyl-imatinib (CGP74588) in human plasma and relevant murine biological matrices. A simple HPLC assay for the individual quantification of imatinib and CGP74588 in murine specimens has not been reported to date. Sample pre-treatment involved liquid–liquid extraction with tert-butyl-methyl ether. Imatinib, CGP74588 (metabolite) and the internal standard 4-hydroxybenzophenone were separated using a narrow bore (2.1 × 150 mm) stainless steel Symmetry C18 column and detected by UV at 265 nm. The mobile phase consisted of 28% (v/v) acetonitrile in 50 mm ammonium acetate buffer pH 6.8 containing 0.005 m 1-octane sulfonic acid and was delivered at 0.2 mL/min. The calibration curve was prepared in blank human plasma and was linear over the dynamic range 10 ng/mL to 10 µg/mL). The accuracy was close to 100% and the within-day and between-day precisions were within the generally accepted 15% range. The validation results showed that the assay was selective and reproducible. This method was applied to study the pharmacokinetics of imatinib and its main metabolite in human and mice. Copyright © 2007 John Wiley & Sons, Ltd." @default.
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• W2100032318 date "2007-01-01" @default.
• W2100032318 modified "2023-10-17" @default.
• W2100032318 title "Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography" @default.
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• W2100032318 doi "https://doi.org/10.1002/bmc.816" @default.
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