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- W2100032972 abstract "Gene expression changes induced by carcinogens may identify differences in molecular function between target and non-target organs. Target organs for benzo[a]pyrene (BaP) carcinogenicity in mice (lung, spleen and forestomach) and three non-target organs (liver, colon and glandular stomach) were investigated for DNA adducts by 32P-postlabelling, for gene expression changes by cDNA microarray and for miRNA expression changes by miRNA microarray after exposure of animals to BaP. BaP-DNA adduct formation occurred in all six organs at levels that did not distinguish between target and non-target. cDNA microarray analysis showed a variety of genes modulated significantly by BaP in the six organs and the overall gene expression patterns were tissue specific. Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs. Additionally, several gene expression changes, such as in Trp53 activation and Stat3 activity suggested some similarities in molecular mechanisms in two target organs (lung and spleen), which were not found in the other four organs. Changes in miRNA expression were generally tissue specific, involving, in total, 21/54 miRNAs significantly up- or down-regulated. Altogether, these findings showed that DNA adduct levels and early gene expression changes did not fully distinguish target from non-target organs. However, mechanisms related to early changes in p53, Stat3 and Wnt/β-catenin pathways may play roles in defining BaP organotropism." @default.
- W2100032972 created "2016-06-24" @default.
- W2100032972 creator A5028913227 @default.
- W2100032972 creator A5034188143 @default.
- W2100032972 creator A5070534184 @default.
- W2100032972 creator A5087622113 @default.
- W2100032972 creator A5088971353 @default.
- W2100032972 date "2014-10-08" @default.
- W2100032972 modified "2023-10-06" @default.
- W2100032972 title "Benzo Equation missing <!-- No EquationSource Format=TEX, only image -->pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice" @default.
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