Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100033601> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2100033601 endingPage "1476" @default.
- W2100033601 startingPage "1470" @default.
- W2100033601 abstract "We have evaluated an anti-autocrine growth factor monoclonal antibody for potential use in the treatment of patients with small-cell lung cancer. The monoclonal antibody, designated 2A11, binds to the C-terminal region of the autocrine growth factor gastrin-releasing peptide and neutralizes its growth-promoting effects in vitro and in vivo. Equilibrium-binding analysis demonstrated that the peptide binds to the antibody (dissociation constant = 1.5 x 10(-10) at least as avidly as it binds to the tumor peptide receptor. Pharmacokinetic studies in normal BALB/c mice demonstrated an initial clearance half-life (alpha t1/2) of 24.3 +/- 4 hours and a secondary clearance half-life (beta t1/2) of 1039.6 +/- 309 hours, and biodistribution studies revealed a distribution pattern which generally reflected blood flow. Single intravenous infusions of 2A11 (20 mg/20-25-kg dogs) into normal mongrel dogs with surgically created gastric fistulas antagonized the stimulatory effects of exogenously infused gastrin-releasing peptide or bombesin on plasma gastrin release and gastric acid secretion. Toxicology studies in normal dogs (with gastric fistulas) infused with 50 mg 2A11 intravenously three times a week for 4 weeks failed to reveal any adverse behavioral, clinical, or pathological effects. Four of six dogs developed an immune response to 2A11. Anti-idiotypic antibodies elicited in two cases did not mimic the functional effects of the peptide. We conclude that the concept of immunoblockade of an autocrine growth factor appears feasible in vivo." @default.
- W2100033601 created "2016-06-24" @default.
- W2100033601 creator A5012428409 @default.
- W2100033601 creator A5021421298 @default.
- W2100033601 creator A5028796764 @default.
- W2100033601 creator A5077585632 @default.
- W2100033601 creator A5082056294 @default.
- W2100033601 creator A5089963107 @default.
- W2100033601 creator A5090206378 @default.
- W2100033601 creator A5091680206 @default.
- W2100033601 date "1991-10-16" @default.
- W2100033601 modified "2023-10-16" @default.
- W2100033601 title "Preclinical Evaluation of an Anti-Autocrine Growth Factor Monoclonal Antibody for Treatment of Patients With Small-Cell Lung Cancer" @default.
- W2100033601 doi "https://doi.org/10.1093/jnci/83.20.1470" @default.
- W2100033601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1656058" @default.
- W2100033601 hasPublicationYear "1991" @default.
- W2100033601 type Work @default.
- W2100033601 sameAs 2100033601 @default.
- W2100033601 citedByCount "33" @default.
- W2100033601 countsByYear W21000336012012 @default.
- W2100033601 countsByYear W21000336012018 @default.
- W2100033601 crossrefType "journal-article" @default.
- W2100033601 hasAuthorship W2100033601A5012428409 @default.
- W2100033601 hasAuthorship W2100033601A5021421298 @default.
- W2100033601 hasAuthorship W2100033601A5028796764 @default.
- W2100033601 hasAuthorship W2100033601A5077585632 @default.
- W2100033601 hasAuthorship W2100033601A5082056294 @default.
- W2100033601 hasAuthorship W2100033601A5089963107 @default.
- W2100033601 hasAuthorship W2100033601A5090206378 @default.
- W2100033601 hasAuthorship W2100033601A5091680206 @default.
- W2100033601 hasConcept C118303440 @default.
- W2100033601 hasConcept C126322002 @default.
- W2100033601 hasConcept C128240485 @default.
- W2100033601 hasConcept C134018914 @default.
- W2100033601 hasConcept C150903083 @default.
- W2100033601 hasConcept C159654299 @default.
- W2100033601 hasConcept C170493617 @default.
- W2100033601 hasConcept C203014093 @default.
- W2100033601 hasConcept C207001950 @default.
- W2100033601 hasConcept C2776986829 @default.
- W2100033601 hasConcept C2776998989 @default.
- W2100033601 hasConcept C2778448772 @default.
- W2100033601 hasConcept C49039625 @default.
- W2100033601 hasConcept C542903549 @default.
- W2100033601 hasConcept C71924100 @default.
- W2100033601 hasConcept C86803240 @default.
- W2100033601 hasConcept C98274493 @default.
- W2100033601 hasConceptScore W2100033601C118303440 @default.
- W2100033601 hasConceptScore W2100033601C126322002 @default.
- W2100033601 hasConceptScore W2100033601C128240485 @default.
- W2100033601 hasConceptScore W2100033601C134018914 @default.
- W2100033601 hasConceptScore W2100033601C150903083 @default.
- W2100033601 hasConceptScore W2100033601C159654299 @default.
- W2100033601 hasConceptScore W2100033601C170493617 @default.
- W2100033601 hasConceptScore W2100033601C203014093 @default.
- W2100033601 hasConceptScore W2100033601C207001950 @default.
- W2100033601 hasConceptScore W2100033601C2776986829 @default.
- W2100033601 hasConceptScore W2100033601C2776998989 @default.
- W2100033601 hasConceptScore W2100033601C2778448772 @default.
- W2100033601 hasConceptScore W2100033601C49039625 @default.
- W2100033601 hasConceptScore W2100033601C542903549 @default.
- W2100033601 hasConceptScore W2100033601C71924100 @default.
- W2100033601 hasConceptScore W2100033601C86803240 @default.
- W2100033601 hasConceptScore W2100033601C98274493 @default.
- W2100033601 hasIssue "20" @default.
- W2100033601 hasLocation W21000336011 @default.
- W2100033601 hasLocation W21000336012 @default.
- W2100033601 hasOpenAccess W2100033601 @default.
- W2100033601 hasPrimaryLocation W21000336011 @default.
- W2100033601 hasRelatedWork W1972651230 @default.
- W2100033601 hasRelatedWork W1996837279 @default.
- W2100033601 hasRelatedWork W2000249325 @default.
- W2100033601 hasRelatedWork W2014821004 @default.
- W2100033601 hasRelatedWork W2033322586 @default.
- W2100033601 hasRelatedWork W2084377343 @default.
- W2100033601 hasRelatedWork W2092197633 @default.
- W2100033601 hasRelatedWork W2129583422 @default.
- W2100033601 hasRelatedWork W2335717743 @default.
- W2100033601 hasRelatedWork W2412314692 @default.
- W2100033601 hasVolume "83" @default.
- W2100033601 isParatext "false" @default.
- W2100033601 isRetracted "false" @default.
- W2100033601 magId "2100033601" @default.
- W2100033601 workType "article" @default.