Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100035285> ?p ?o ?g. }
- W2100035285 endingPage "3631" @default.
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- W2100035285 abstract "Medicinal Inorganic Chemistry offers the high diversity of metal coordination chemistry for the development of bioactive compounds for therapeutic or diagnostic medicinal purposes. The design of novel metal-based antitumor agents occupies a privileged position in this discovery process. On the other hand, the research on metal-based radiopharmaceuticals for therapy and imaging is a subarea of high priority and development. This review describes therapeutic applications of metal compounds directed towards hypoxic tissues. Strategies in the search for new bioreductive metal-based prodrugs will be discussed. In addition, approaches for the imaging of hypoxic tissues by using metal radionuclides will be exemplified. Keywords: Hypoxia selectivity, metal-based compounds, bioreduction, bioreductive metal-based prodrugs, nitrogen mustards, aromatic N-oxides, quinoxalines and thiosemicarbazones metal complexes, Hypoxic Tissues, diagnostic medicinal purposes, medicinal purposes, solubility, lipophilicity, activation by bioreduction, magnetic resonance imaging (MRI), antitumoral activity of cisplatin, metal-based anticancer drugs, anticancer chemotherapy, organic chemotherapeutics, promoting metastasis and angiogenesis, slow-growing hypoxic solid tumors, hypoxia-selective cytotoxins, conventional antitumoral drugs, nitroaromatics, labile high-spin Co(II) octahedral complexes, sta-ble Co(II) hexaaquo species, bidentate ali-phatic nitrogen mustards, aerobic cytotoxicity, aziridine complexes, hypoxia selective cytotoxins, aliphatic mustards, polyazamacrocyclic nitrogen mustards, Nitrogen mustard ligands, bioreductive prodrugs, tetradentate polyazamacrocyclic nitrogen, pyrrolo[3,2-f]quinoline analogues, quantitative radiolytic, animal metastatic foci, redox cycling process, superoxide forma-tion, antecedent, Tirapazamine, bioreduction and radiotherapy, Chemo preventive, anti-tumor effects, vanadium-prodrug complex, normoxia, hypoxia, superoxide dismutase activity, Tirapazamine [62], Mitomycine C, Misonidazole, electrochemical behavior, hydrophilic solvents, Metal-Radionuclide Radiopharmaceuti-cals, diabetic retinopathy, radiodiagnosis, radiotherapy purposes, techniques gamma scintigraphy, annihilation radiation, Cu-bis(thiosemicarbazone) complexes, myocardium, potential radiotherapeutic agent, rapid acid-catalyzed dissociation, subsequent back-oxidation, PET tracers, necrotic tissue, hypoxia-selective nitroimidazoles, amineoxime-type chelators, non nitro-aryl-based ra-diotracer, novel potential hy-poxic-tissue tracers, Bioreduced in Biological Media, activated by bioreduction, chelating bioligands, antitumor agents, cisplatin, carboplatin, oxaliplatin, 2-methyl-5-nitro-imidazole derivatives, PnAO -1-(2-nitroimidazole), PnAO-5-0xa-6-(2-nitroimidazole), Pt(IV) complexes reduction potentials, anticancer agents, hypoxic solid tumors" @default.
- W2100035285 created "2016-06-24" @default.
- W2100035285 creator A5032771544 @default.
- W2100035285 date "2010-11-01" @default.
- W2100035285 modified "2023-10-16" @default.
- W2100035285 title "Potential Therapeutic Applications of Metal Compounds Directed Towards Hypoxic Tissues" @default.
- W2100035285 cites W153058074 @default.
- W2100035285 cites W1605765845 @default.
- W2100035285 cites W1682474579 @default.
- W2100035285 cites W1848872330 @default.
- W2100035285 cites W1943960710 @default.
- W2100035285 cites W1965741433 @default.
- W2100035285 cites W1970343501 @default.
- W2100035285 cites W1970401962 @default.
- W2100035285 cites W1971606784 @default.
- W2100035285 cites W1976395096 @default.
- W2100035285 cites W1977060058 @default.
- W2100035285 cites W1977103302 @default.
- W2100035285 cites W1979266847 @default.
- W2100035285 cites W1979652228 @default.
- W2100035285 cites W1980594297 @default.
- W2100035285 cites W1981018826 @default.
- W2100035285 cites W1986024777 @default.
- W2100035285 cites W1993784723 @default.
- W2100035285 cites W1995852936 @default.
- W2100035285 cites W1996124148 @default.
- W2100035285 cites W1996144373 @default.
- W2100035285 cites W1997213816 @default.
- W2100035285 cites W1997326839 @default.
- W2100035285 cites W1997386494 @default.
- W2100035285 cites W1997453167 @default.
- W2100035285 cites W1997565922 @default.
- W2100035285 cites W1999374190 @default.
- W2100035285 cites W2001976945 @default.
- W2100035285 cites W2002109883 @default.
- W2100035285 cites W2002237723 @default.
- W2100035285 cites W2004083041 @default.
- W2100035285 cites W2006167657 @default.
- W2100035285 cites W2008018518 @default.
- W2100035285 cites W2008973346 @default.
- W2100035285 cites W2011134969 @default.
- W2100035285 cites W2014588550 @default.
- W2100035285 cites W2015112776 @default.
- W2100035285 cites W2015277552 @default.
- W2100035285 cites W2019735253 @default.
- W2100035285 cites W2020820485 @default.
- W2100035285 cites W2023539435 @default.
- W2100035285 cites W2024511476 @default.
- W2100035285 cites W2024796877 @default.
- W2100035285 cites W2026971934 @default.
- W2100035285 cites W2027935944 @default.
- W2100035285 cites W2027957081 @default.
- W2100035285 cites W2028459481 @default.
- W2100035285 cites W2028599275 @default.
- W2100035285 cites W2034243080 @default.
- W2100035285 cites W2035622437 @default.
- W2100035285 cites W2040675733 @default.
- W2100035285 cites W2042204199 @default.
- W2100035285 cites W2045329548 @default.
- W2100035285 cites W2045355737 @default.
- W2100035285 cites W2046939258 @default.
- W2100035285 cites W2049909559 @default.
- W2100035285 cites W2053530934 @default.
- W2100035285 cites W2054058685 @default.
- W2100035285 cites W2054555984 @default.
- W2100035285 cites W2056685020 @default.
- W2100035285 cites W2056995285 @default.
- W2100035285 cites W2057404035 @default.
- W2100035285 cites W2059737561 @default.
- W2100035285 cites W2063177561 @default.
- W2100035285 cites W2065083690 @default.
- W2100035285 cites W2066965808 @default.
- W2100035285 cites W2068163881 @default.
- W2100035285 cites W2073128395 @default.
- W2100035285 cites W2076072288 @default.
- W2100035285 cites W2076940285 @default.
- W2100035285 cites W207850226 @default.
- W2100035285 cites W2078994282 @default.
- W2100035285 cites W2079666288 @default.
- W2100035285 cites W2080304540 @default.
- W2100035285 cites W2080899558 @default.
- W2100035285 cites W2081814446 @default.
- W2100035285 cites W2083421040 @default.
- W2100035285 cites W2087709256 @default.
- W2100035285 cites W2094633478 @default.
- W2100035285 cites W2095190633 @default.
- W2100035285 cites W2104926349 @default.
- W2100035285 cites W2105983804 @default.
- W2100035285 cites W2109511270 @default.
- W2100035285 cites W2112891180 @default.
- W2100035285 cites W2113161125 @default.
- W2100035285 cites W2116150717 @default.
- W2100035285 cites W2119073618 @default.
- W2100035285 cites W2119338352 @default.
- W2100035285 cites W2121944811 @default.
- W2100035285 cites W2122210611 @default.
- W2100035285 cites W2125257427 @default.
- W2100035285 cites W2126559170 @default.