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- W2100035597 abstract "Patients with Lennox–Gastaut syndrome (persistent tonic, myoclonic, and astatic seizures) have a poor prognosis. Seizures occur daily in most individuals and persist in 60 to 80%.1 Callosotomy may reduce seizure frequency, particularly for those with astatic seizures, but complete control is rare.1 A preliminary report suggested that vagus nerve stimulation (VNS) might improve seizure control and quality of life,2 although to our knowledge no completely seizure-free outcome for patients with this syndrome has been reported following this approach.The patient was a 22-year-old white man referred to our clinic at age 18 years for drug-resistant epilepsy with astatic seizures. High-field (1.5 T) brain MRI showed an abnormal arrangement of the sulcal pattern in the frontal lobes and diffuse polymicrogyria in the frontal, temporal, insular, and parietal lobes (figure, A through C). Brain SPECT scanning showed hypoperfusion of the right fronto-parieto-occipital regions and the left parieto-occipital regions. The patient had severe mental retardation, an IQ of 47 (Raven …" @default.
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- W2100035597 date "2004-10-25" @default.
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- W2100035597 title "Delayed response of seizures with vagus nerve stimulation in Lennox-Gastaut syndrome" @default.
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- W2100035597 doi "https://doi.org/10.1212/01.wnl.0000141854.58301.4c" @default.
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