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• W2100037161 abstract "ABSTRACT To elucidate the function of an unknown regulator in Streptomyces , differences in phenotype and antibiotic production between a deletion mutant and a wild-type strain (WT) were compared. These differences are easily hidden by complex media. To determine the specific nutrient conditions that reveal such differences, we used a multiwell method containing different nutrients along with bromothymol blue. We found several nutrients that provide key information on characterization conditions. By comparing the growth of wild-type and mutant strains on screened nutrients, we were able to measure growth, organic acid production, and antibiotic production for the elucidation of regulator function. As a result of this method, a member of the MarR-like regulator family, SCO5405 (AbsC), was newly characterized to control pyruvate dehydrogenase in Streptomyces coelicolor . Deletion of SCO5405 increased the pH of the culture broth due to decreased production of organic acids such as pyruvate and α-ketoglutarate and increased extracellular actinorhodin (ACT) production in minimal medium containing glucose and alanine (MMGA). This method could therefore be a high-throughput method for the characterization of unknown regulators." @default.
• W2100037161 created "2016-06-24" @default.
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• W2100037161 date "2010-06-01" @default.
• W2100037161 modified "2023-09-27" @default.
• W2100037161 title "Rapid Functional Screening of <i>Streptomyces coelicolor</i> Regulators by Use of a pH Indicator and Application to the MarR-Like Regulator AbsC" @default.
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• W2100037161 doi "https://doi.org/10.1128/aem.02617-09" @default.
• W2100037161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2876474" @default.
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