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• W2100037436 abstract "Bovine herpesvirus 1 (BoHV-1) causes recurrent respiratory and genital infections in cattle and predisposes them to lethal secondary infections. While modified live and killed BoHV-1 vaccines exist, these are not without problems. Development of an effective DNA vaccine for BoHV-1 has the potential to address these issues. As a strategy to enhance DNA vaccine immunity, a plasmid encoding the bovine neutrophil beta-defensin 3 (BNBD3) as a fusion with truncated glycoprotein D (tgD) and a mix of two plasmids encoding BNBD3 and tgD were tested in mice and cattle. In mice, coadministration of BNBD3 on the separate plasmid enhanced the tgD-induced gamma interferon (IFN-γ) response but not the antibody response. BNBD3 fused to tgD did not affect the antibody levels or the number of IFN-γ-secreting cells but increased the induction of tgD-specific cytotoxic T lymphocytes (CTLs). In cattle, the addition of BNBD3 as a fusion construct also modified the immune response. While the IgG and virus-neutralizing antibody levels were not affected, the number of IFN-γ-secreting cells was increased after BoHV-1 challenge, specifically the CD8(+) IFN-γ(+) T cells, including CD8(+) IFN-γ(+) CD25(+) CTLs. While reduced virus shedding, rectal temperature, and weight loss were observed, the level of protection was comparable to that observed in pMASIA-tgD-vaccinated animals. These data show that coadministration of BNBD3 with a protective antigen as a fusion in a DNA vaccine strengthened the Th1 bias and increased cell-mediated immune responses but did not enhance protection from BoHV-1 infection." @default.
• W2100037436 created "2016-06-24" @default.
• W2100037436 creator A5001431248 @default.
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• W2100037436 creator A5079330921 @default.
• W2100037436 creator A5084967847 @default.
• W2100037436 date "2014-04-01" @default.
• W2100037436 modified "2023-10-05" @default.
• W2100037436 title "Inclusion of the Bovine Neutrophil Beta-Defensin 3 with Glycoprotein D of Bovine Herpesvirus 1 in a DNA Vaccine Modulates Immune Responses of Mice and Cattle" @default.
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• W2100037436 doi "https://doi.org/10.1128/cvi.00696-13" @default.
• W2100037436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3993117" @default.
• W2100037436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24451331" @default.
• W2100037436 hasPublicationYear "2014" @default.
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