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• W2100038242 endingPage "R610" @default.
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• W2100038242 abstract "We investigated the effect of resistance exercise and feeding on the activation of signaling proteins involved in translation initiation. Nine young men (23.7 ± 0.41 yr; BMI = 25.5 ± 1.0 kg/m 2 ; means ± SE) were tested twice after they performed a strenuous bout of unilateral resistance exercise, such that their contralateral leg acted as a nonexercised comparator, in either the fasted and fed [1,000 kJ, each 90 min (3 doses): 10 g protein, 41 g carbohydrate, 4 g fat] states. Muscle biopsies were obtained 6 h postexercise from both legs, resulting in four experimental conditions: rest-fasted, rest-fed, exercise-fasted, and exercise-fed. Feeding increased PKB/Akt (Ser473) phosphorylation ( P < 0.05), while exercise increased the phosphorylation of Akt and the downstream 70 kDa S6 protein kinase (p70 S6K1 , Thr389) and ribosomal protein S6 (rpS6, Ser235/236, Ser240/244; all P < 0.05). The combination of resistance exercise and feeding increased the phosphorylation of p70 S6K1 (Thr389) and rpS6 (Ser240/244) above exercise alone ( P < 0.05). Exercise also reduced phosphorylation of the catalytic epsilon subunit of eukaryotic initiation factor 2B (eIF2Bε, Ser540; P < 0.05). Mammalian target of rapamycin (mTOR, Ser2448), glycogen synthase kinase-3β (GSK-3β, Ser9), and focal adhesion kinase (FAK, Tyr 576/577 ) phosphorylation were unaffected by either feeding or resistance exercise (all P > 0.14). In summary, feeding resulted in phosphorylation of Akt, while resistance exercise stimulated phosphorylation of Akt, p70 S6K1 , rpS6, and dephosphorylation eIF2Bε with a synergistic effect of feeding and exercise on p70 S6K1 and its downstream target rpS6. We conclude that resistance exercise potentiates the effect of feeding on the phosphorylation and presumably activation of critical proteins involved in the regulation of muscle protein synthesis in young men." @default.
• W2100038242 created "2016-06-24" @default.
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• W2100038242 date "2008-08-01" @default.
• W2100038242 modified "2023-10-15" @default.
• W2100038242 title "Resistance exercise decreases eIF2Bε phosphorylation and potentiates the feeding-induced stimulation of p70^S6K1 and rpS6 in young men" @default.
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• W2100038242 doi "https://doi.org/10.1152/ajpregu.00097.2008" @default.
• W2100038242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18565837" @default.
• W2100038242 hasPublicationYear "2008" @default.
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