FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100040373> ?p ?o ?g. }

• W2100040373 endingPage "734" @default.
• W2100040373 startingPage "728" @default.
• W2100040373 abstract "An increased plasma concentration of von Willebrand factor (vWF) is detected in individuals with many infectious diseases and is accepted as a marker of endothelium activation and prothrombotic condition. To determine whether ExoU, a Pseudomonas aeruginosa cytotoxin with proinflammatory activity, enhances the release of vWF, microvascular endothelial cells were infected with the ExoU-producing PA103 P. aeruginosa strain or an exoU-deficient mutant. Significantly increased vWF concentrations were detected in conditioned medium and subendothelial extracellular matrix from cultures infected with the wild-type bacteria, as determined by enzyme-linked immunoassays. PA103-infected cells also released higher concentrations of procoagulant microparticles containing increased amounts of membrane-associated vWF, as determined by flow cytometric analyses of cell culture supernatants. Both flow cytometry and confocal microscopy showed that increased amounts of vWF were associated with cytoplasmic membranes from cells infected with the ExoU-producing bacteria. PA103-infected cultures exposed to platelet suspensions exhibited increased percentages of cells with platelet adhesion. Because no modulation of the vWF mRNA levels was detected by reverse transcription-polymerase chain reaction assays in PA103-infected cells, ExoU is likely to have induced the release of vWF from cytoplasmic stores rather than vWF gene transcription. Such release is likely to modify the thromboresistance of microvascular endothelial cells." @default.
• W2100040373 created "2016-06-24" @default.
• W2100040373 creator A5010439450 @default.
• W2100040373 creator A5038442366 @default.
• W2100040373 creator A5048496861 @default.
• W2100040373 creator A5064906036 @default.
• W2100040373 creator A5069965109 @default.
• W2100040373 creator A5081229616 @default.
• W2100040373 creator A5088553782 @default.
• W2100040373 date "2012-09-01" @default.
• W2100040373 modified "2023-10-18" @default.
• W2100040373 title "The infection of microvascular endothelial cells with ExoU-producing Pseudomonas aeruginosa triggers the release of von Willebrand factor and platelet adhesion" @default.
• W2100040373 cites W1508082942 @default.
• W2100040373 cites W173698071 @default.
• W2100040373 cites W1842693293 @default.
• W2100040373 cites W1979838917 @default.
• W2100040373 cites W1985909969 @default.
• W2100040373 cites W1999364304 @default.
• W2100040373 cites W2001291333 @default.
• W2100040373 cites W2001786965 @default.
• W2100040373 cites W2003961381 @default.
• W2100040373 cites W2010121348 @default.
• W2100040373 cites W2012716202 @default.
• W2100040373 cites W2021802040 @default.
• W2100040373 cites W2034825883 @default.
• W2100040373 cites W2044505929 @default.
• W2100040373 cites W2047204651 @default.
• W2100040373 cites W2054657407 @default.
• W2100040373 cites W2055882902 @default.
• W2100040373 cites W2056604234 @default.
• W2100040373 cites W2089727747 @default.
• W2100040373 cites W2092249430 @default.
• W2100040373 cites W2098586577 @default.
• W2100040373 cites W2106843173 @default.
• W2100040373 cites W2110971703 @default.
• W2100040373 cites W2116202774 @default.
• W2100040373 cites W2120126668 @default.
• W2100040373 cites W2122082665 @default.
• W2100040373 cites W2126254515 @default.
• W2100040373 cites W2136711242 @default.
• W2100040373 cites W2137976684 @default.
• W2100040373 cites W2152936026 @default.
• W2100040373 cites W2154382837 @default.
• W2100040373 cites W2156887090 @default.
• W2100040373 cites W2158102238 @default.
• W2100040373 cites W2159922426 @default.
• W2100040373 cites W98274933 @default.
• W2100040373 doi "https://doi.org/10.1590/s0074-02762012000600004" @default.
• W2100040373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22990960" @default.
• W2100040373 hasPublicationYear "2012" @default.
• W2100040373 type Work @default.
• W2100040373 sameAs 2100040373 @default.
• W2100040373 citedByCount "4" @default.
• W2100040373 countsByYear W21000403732017 @default.
• W2100040373 countsByYear W21000403732021 @default.
• W2100040373 countsByYear W21000403732022 @default.
• W2100040373 crossrefType "journal-article" @default.
• W2100040373 hasAuthorship W2100040373A5010439450 @default.
• W2100040373 hasAuthorship W2100040373A5038442366 @default.
• W2100040373 hasAuthorship W2100040373A5048496861 @default.
• W2100040373 hasAuthorship W2100040373A5064906036 @default.
• W2100040373 hasAuthorship W2100040373A5069965109 @default.
• W2100040373 hasAuthorship W2100040373A5081229616 @default.
• W2100040373 hasAuthorship W2100040373A5088553782 @default.
• W2100040373 hasBestOaLocation W21000403731 @default.
• W2100040373 hasConcept C123012128 @default.
• W2100040373 hasConcept C134018914 @default.
• W2100040373 hasConcept C153911025 @default.
• W2100040373 hasConcept C164027704 @default.
• W2100040373 hasConcept C185592680 @default.
• W2100040373 hasConcept C202751555 @default.
• W2100040373 hasConcept C203014093 @default.
• W2100040373 hasConcept C2776914184 @default.
• W2100040373 hasConcept C2776992346 @default.
• W2100040373 hasConcept C2777637488 @default.
• W2100040373 hasConcept C2779394231 @default.
• W2100040373 hasConcept C523546767 @default.
• W2100040373 hasConcept C54355233 @default.
• W2100040373 hasConcept C553184892 @default.
• W2100040373 hasConcept C55493867 @default.
• W2100040373 hasConcept C86803240 @default.
• W2100040373 hasConcept C89423630 @default.
• W2100040373 hasConcept C89560881 @default.
• W2100040373 hasConceptScore W2100040373C123012128 @default.
• W2100040373 hasConceptScore W2100040373C134018914 @default.
• W2100040373 hasConceptScore W2100040373C153911025 @default.
• W2100040373 hasConceptScore W2100040373C164027704 @default.
• W2100040373 hasConceptScore W2100040373C185592680 @default.
• W2100040373 hasConceptScore W2100040373C202751555 @default.
• W2100040373 hasConceptScore W2100040373C203014093 @default.
• W2100040373 hasConceptScore W2100040373C2776914184 @default.
• W2100040373 hasConceptScore W2100040373C2776992346 @default.
• W2100040373 hasConceptScore W2100040373C2777637488 @default.
• W2100040373 hasConceptScore W2100040373C2779394231 @default.
• W2100040373 hasConceptScore W2100040373C523546767 @default.
• W2100040373 hasConceptScore W2100040373C54355233 @default.
• W2100040373 hasConceptScore W2100040373C553184892 @default.
• W2100040373 hasConceptScore W2100040373C55493867 @default.

• next