FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100041977> ?p ?o ?g. }

• W2100041977 endingPage "107" @default.
• W2100041977 startingPage "98" @default.
• W2100041977 abstract "The discovery and validation of biomarkers in neurological and neurodegenerative diseases is an important challenge for early diagnosis of disease and for the development of therapeutics. Epilepsy is often a consequence of brain insults such as traumatic brain injury or stroke, but as yet no biomarker exists to predict the development of epilepsy in patients at risk. Given the complexity of epilepsy, it is unlikely that a single biomarker is sufficient for this purpose, but a combinatorial approach may be needed to overcome the challenge of individual variability and disease heterogeneity. The goal of the present prospective study in the lithium-pilocarpine model of epilepsy in rats was to determine the discriminative utility of combinations of phenotypic biomarkers by examining their ability to predict epilepsy. For this purpose, we used a recent model refinement that allows comparing rats that will or will not develop spontaneous recurrent seizures (SRS) after pilocarpine-induced status epilepticus (SE). Potential biomarkers included in our study were seizure threshold and seizure severity in response to timed i.v. infusion of pentylenetetrazole (PTZ) and behavioral alterations determined by a battery of tests during the three weeks following SE. Three months after SE, video/EEG monitoring was used to determine which rats had developed SRS. To determine whether a biomarker or combination of biomarkers performed better than chance at predicting epilepsy after SE, derived data underwent receiver operating characteristic (ROC) curve analyses. When comparing rats with and without SRS and sham controls, the best intergroup discrimination was obtained by combining all measurements, resulting in a ROC area under curve (AUC) of 0.9592 (P<0.01), indicating an almost perfect discrimination or accuracy to predict development of SRS. These data indicate that a combinatorial biomarker approach may overcome the challenge of individual variability in the prediction of epilepsy." @default.
• W2100041977 created "2016-06-24" @default.
• W2100041977 creator A5009656924 @default.
• W2100041977 creator A5010235451 @default.
• W2100041977 date "2015-12-01" @default.
• W2100041977 modified "2023-09-25" @default.
• W2100041977 title "Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium–pilocarpine model of temporal lobe epilepsy in rats" @default.
• W2100041977 cites W1480925601 @default.
• W2100041977 cites W1893459668 @default.
• W2100041977 cites W1964869332 @default.
• W2100041977 cites W1965712297 @default.
• W2100041977 cites W1968834225 @default.
• W2100041977 cites W1969438101 @default.
• W2100041977 cites W1970117905 @default.
• W2100041977 cites W1985736947 @default.
• W2100041977 cites W1987735289 @default.
• W2100041977 cites W1990539313 @default.
• W2100041977 cites W1991323299 @default.
• W2100041977 cites W1992574314 @default.
• W2100041977 cites W1995679204 @default.
• W2100041977 cites W2010425177 @default.
• W2100041977 cites W2017500569 @default.
• W2100041977 cites W2018413664 @default.
• W2100041977 cites W2019141334 @default.
• W2100041977 cites W2022707569 @default.
• W2100041977 cites W2027181597 @default.
• W2100041977 cites W2028127492 @default.
• W2100041977 cites W2031616221 @default.
• W2100041977 cites W2035744498 @default.
• W2100041977 cites W2036587077 @default.
• W2100041977 cites W2040677029 @default.
• W2100041977 cites W2045932599 @default.
• W2100041977 cites W2050074235 @default.
• W2100041977 cites W2055907399 @default.
• W2100041977 cites W2063416740 @default.
• W2100041977 cites W2066284829 @default.
• W2100041977 cites W2067546980 @default.
• W2100041977 cites W2068138485 @default.
• W2100041977 cites W2073031669 @default.
• W2100041977 cites W2073559330 @default.
• W2100041977 cites W2080601011 @default.
• W2100041977 cites W2084708682 @default.
• W2100041977 cites W2087619608 @default.
• W2100041977 cites W2088784831 @default.
• W2100041977 cites W2113113253 @default.
• W2100041977 cites W2113752130 @default.
• W2100041977 cites W2118789647 @default.
• W2100041977 cites W2120155377 @default.
• W2100041977 cites W2120320261 @default.
• W2100041977 cites W2122793412 @default.
• W2100041977 cites W2126274301 @default.
• W2100041977 cites W2130553763 @default.
• W2100041977 cites W2139298313 @default.
• W2100041977 cites W2765754703 @default.
• W2100041977 doi "https://doi.org/10.1016/j.yebeh.2015.09.028" @default.
• W2100041977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26539702" @default.
• W2100041977 hasPublicationYear "2015" @default.
• W2100041977 type Work @default.
• W2100041977 sameAs 2100041977 @default.
• W2100041977 citedByCount "22" @default.
• W2100041977 countsByYear W21000419772015 @default.
• W2100041977 countsByYear W21000419772016 @default.
• W2100041977 countsByYear W21000419772017 @default.
• W2100041977 countsByYear W21000419772018 @default.
• W2100041977 countsByYear W21000419772019 @default.
• W2100041977 countsByYear W21000419772020 @default.
• W2100041977 countsByYear W21000419772021 @default.
• W2100041977 countsByYear W21000419772022 @default.
• W2100041977 crossrefType "journal-article" @default.
• W2100041977 hasAuthorship W2100041977A5009656924 @default.
• W2100041977 hasAuthorship W2100041977A5010235451 @default.
• W2100041977 hasConcept C104317684 @default.
• W2100041977 hasConcept C124535831 @default.
• W2100041977 hasConcept C126322002 @default.
• W2100041977 hasConcept C15744967 @default.
• W2100041977 hasConcept C169760540 @default.
• W2100041977 hasConcept C2777204577 @default.
• W2100041977 hasConcept C2777341932 @default.
• W2100041977 hasConcept C2778186239 @default.
• W2100041977 hasConcept C2779134260 @default.
• W2100041977 hasConcept C2781099131 @default.
• W2100041977 hasConcept C2781197716 @default.
• W2100041977 hasConcept C46111723 @default.
• W2100041977 hasConcept C522805319 @default.
• W2100041977 hasConcept C55493867 @default.
• W2100041977 hasConcept C57236427 @default.
• W2100041977 hasConcept C58471807 @default.
• W2100041977 hasConcept C71924100 @default.
• W2100041977 hasConcept C86803240 @default.
• W2100041977 hasConceptScore W2100041977C104317684 @default.
• W2100041977 hasConceptScore W2100041977C124535831 @default.
• W2100041977 hasConceptScore W2100041977C126322002 @default.
• W2100041977 hasConceptScore W2100041977C15744967 @default.
• W2100041977 hasConceptScore W2100041977C169760540 @default.
• W2100041977 hasConceptScore W2100041977C2777204577 @default.
• W2100041977 hasConceptScore W2100041977C2777341932 @default.
• W2100041977 hasConceptScore W2100041977C2778186239 @default.
• W2100041977 hasConceptScore W2100041977C2779134260 @default.

• next