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- W2100042209 abstract "Dienogest is a progestogen that combines the pharmacological properties of 19-norprogestins and progesterone derivatives. Dienogest has a potent effect on endometrial tissue, producing antiproliferative effects on endometriotic cells, as well as anti-inflammatory and antiangiogenic actions. Dienogest has been systematically investigated for the treatment of endometriosis through comprehensive study programs in Europe and Japan. Clinical experience of dienogest at 2 mg daily orally demonstrates that it significantly reduces endometriotic lesions and provides effective pain relief comparable to the current efficacy standard, combined with a favorable safety and tolerability profile that allows long-term use. Study data over 15 months show sustained pain relief and low incidences of treatment-related adverse events. As with other progestogens, spotting or breakthrough bleeds are common, but usually lessen during long-term treatment. Dienogest does not produce antiestrogenic side effects, such as bone mass loss. This article reviews the evidence for the use of dienogest in endometriosis." @default.
- W2100042209 created "2016-06-24" @default.
- W2100042209 creator A5043943489 @default.
- W2100042209 date "2011-01-01" @default.
- W2100042209 modified "2023-10-17" @default.
- W2100042209 title "Dienogest: an oral progestogen for the treatment of endometriosis" @default.
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- W2100042209 doi "https://doi.org/10.1586/eog.10.71" @default.
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