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• W2100042702 abstract "<h3>Background</h3> Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce dopaminergic neuron degeneration in animal models of Parkinson disease (PD). However, no epidemiological data have been available on NSAID use and the risk of PD. <h3>Objective</h3> To investigate prospectively whether the use of nonaspirin NSAIDs or aspirin is associated with decreased PD risk. <h3>Design, Settings, and Participants</h3> Prospective cohorts of 44 057 men and 98 845 women free of PD, stroke, or cancer (Health Professionals Follow-up Study, 1986-2000, and Nurses' Health Study, 1980-1998). <h3>Main Outcome Measure</h3> Newly diagnosed PD. <h3>Results</h3> We documented 415 incident PD cases (236 men and 179 women). Participants who reported regular use of nonaspirin NSAIDs at the beginning of the study had a lower risk of PD than nonregular users during the follow-up; the pooled multivariate relative risk was 0.55 (95% confidence interval, 0.32-0.96,<i>P</i>= .04). Compared with nonusers, a nonsignificantly lower risk of PD was also observed among men and women who took 2 or more tablets of aspirin per day (relative risk, 0.56; 95% confidence interval, 0.26-1.21). <h3>Conclusion</h3> These findings are consistent with the hypothesis that use of NSAIDs may delay or prevent the onset of PD." @default.
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• W2100042702 date "2003-08-01" @default.
• W2100042702 modified "2023-10-11" @default.
• W2100042702 title "Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease" @default.
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• W2100042702 doi "https://doi.org/10.1001/archneur.60.8.1059" @default.
• W2100042702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12925360" @default.
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