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• W2100043179 abstract "Thyroid-stimulating hormone (TSH)-producing cells of the pars tuberalis (PT) display distinct characteristics that differ from those of the pars distalis (PD). The mRNA expression of TSHβ and α GSU in PT has a circadian rhythm and is inhibited by melatonin via melatonin receptor type 1; however, the detailed regulatory mechanism for TSH β expression in the PT remains unclear. To identify the factors that affect PT, a microarray analysis was performed on laser-captured PT tissue to screen for genes coding for receptors that are abundantly expressed in the PT. In the PT, we found high expression of the KA2 , which is an ionotropic glutamic acid receptor (iGluR). In addition, the amino acid transporter A2 ( ATA2 ), also known as the glutamine transporter, and glutaminase ( GLS ), as well as GLS2 , were highly expressed in the PT compared to the PD. We examined the effects of glutamine and glutamic acid on TSH β expression and α GSU expression in PT slice cultures. l -Glutamine and l -glutamic acid significantly stimulated TSH β expression in PT slices after 2- and 4-h treatments, and the effect of l -glutamic acid was stronger than that of l -glutamine. In contrast, treatment with glutamine and glutamic acid did not affect α GSU expression in the PT or the expression of TSH β or α GSU in the PD. These results strongly suggest that glutamine is taken up by PT cells through ATA2 and that glutamic acid locally converted from glutamine by Gls induces TSH β expression via the KA2 in an autocrine and/or paracrine manner in the PT." @default.
• W2100043179 created "2016-06-24" @default.
• W2100043179 creator A5007166081 @default.
• W2100043179 creator A5027321893 @default.
• W2100043179 creator A5044734833 @default.
• W2100043179 date "2012-01-04" @default.
• W2100043179 modified "2023-10-16" @default.
• W2100043179 title "Glutamine and glutamic acid enhance thyroid-stimulating hormone β subunit mRNA expression in the rat pars tuberalis" @default.
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• W2100043179 doi "https://doi.org/10.1530/joe-11-0388" @default.
• W2100043179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22219301" @default.
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