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• W2100044473 abstract "Phenothiazine analogues have been tested for their effect on calcium uptake into platelet membrane vesicles and on ionophore-induced platelet activation, both phenomena being Ca2+-dependent. Both calcium uptake into membrane vesicles and ionophore-induced platelet activation were inhibited by the drugs. Evidence for two inhibitors as potent as chlorpromazine and trifluoperazine was found. These drugs are apparently competitive inhibitors of calcium uptake. A structure-activity relationship has been established. The data suggest that the phenothiazines are able to inhibit calmodulin-insensitive calcium uptake of platelet membrane vesicles and that therefore they cannot be assumed to be selective inhibitors of calmodulin interactions under all circumstances." @default.
• W2100044473 created "2016-06-24" @default.
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• W2100044473 date "1984-03-01" @default.
• W2100044473 modified "2023-10-17" @default.
• W2100044473 title "Relationship between structure of phenothiazine analogues and their activity on platelet calcium fluxes" @default.
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• W2100044473 doi "https://doi.org/10.1111/j.1476-5381.1984.tb10104.x" @default.
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