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- W2100044474 abstract "Background Melanoma is the most aggressive skin cancer due to its high metastatic propensity and resistance to most traditional chemotherapeutic drugs [1,2]. At early stage melanoma can be cured by surgical excision, whereas metastatic melanoma is a highly lethal condition. To understand melanoma progression is crucial identify mutations that are involved in making an individual melanoma competent for metastatic spread. The most frequent known oncogenic mutation in melanoma is BRAF-V600E and several whole exome sequencing studies have revealed numerous other alterations [3-6]. It is well established that the aggressive behavior of melanoma is highly correlated with histological features, such as the thickness of the primary tumor and the mitotic index. Here we performed whole exome sequencing of 5 thin ( 4mm in thickness) primary melanomas compared to matchednormal DNA." @default.
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- W2100044474 date "2015-01-01" @default.
- W2100044474 modified "2023-09-26" @default.
- W2100044474 title "Exome sequencing in primary melanoma identifies novel drivers of melanoma progression" @default.
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- W2100044474 doi "https://doi.org/10.1186/1479-5876-13-s1-p2" @default.
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