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- W2100044667 abstract "Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these fibrous proteins. Its catalytic activity depends upon both its copper cofactor and a unique carbonyl cofactor and has been shown to extend to a variety of basic globular proteins, including histone H1. Although the three-dimensional structure of LO has yet to be determined, the present treatise offers hypotheses based upon its primary sequence, which may underlie the prominent electrostatic component of its unusual substrate specificity as well as the catalysis-suppressing function of the propeptide domain of prolysyl oxidase. Recent studies have demonstrated that LO appears to function within the cell in a manner, which strongly modifies cellular activity. Newly discovered LO-like proteins also likely play unique roles in biology." @default.
- W2100044667 created "2016-06-24" @default.
- W2100044667 creator A5028611798 @default.
- W2100044667 creator A5069694476 @default.
- W2100044667 date "2003-02-04" @default.
- W2100044667 modified "2023-10-11" @default.
- W2100044667 title "Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell" @default.
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- W2100044667 doi "https://doi.org/10.1002/jcb.10413" @default.
- W2100044667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12577300" @default.
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