FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100044668> ?p ?o ?g. }

• W2100044668 endingPage "37" @default.
• W2100044668 startingPage "27" @default.
• W2100044668 abstract "The Haemophilus surface fibril (Hsf) is an extraordinary large (2413 amino acids) trimeric autotransporter, present in all encapsulated Haemophilus influenzae. It contributes to virulence by directly functioning as an adhesin. Furthermore, Hsf recruits the host factor vitronectin thereby inhibiting the host innate immune response resulting in enhanced survival in serum. Here we observed by electron microscopy that Hsf appears as an 100 nm long fibril at the bacterial surface albeit the length is approximately 200 nm according to a bioinformatics based model. To unveil this discrepancy, we denaturated Hsf at the surface of Hib by using guanidine hydrochloride (GuHCl). Partial denaturation induced in the presence of GuHCl unfolded the Hsf molecules, and resulted in an increased length of fibres in comparison to the native trimeric form. Importantly, our findings were also verified by E. coli expressing Hsf at its surface. In addition, a set of Hsf-specific peptide antibodies also indicated that the N-terminal of Hsf is located near the C-terminal at the base of the fibril. Taken together, our results demonstrated that Hsf is not a straight molecule but is folded and doubled over. This is the first report that provides the unique structural features of the trimeric autotransporter Hsf." @default.
• W2100044668 created "2016-06-24" @default.
• W2100044668 creator A5009914609 @default.
• W2100044668 creator A5029624579 @default.
• W2100044668 creator A5045374933 @default.
• W2100044668 creator A5048707669 @default.
• W2100044668 creator A5061685613 @default.
• W2100044668 creator A5070625264 @default.
• W2100044668 creator A5087600237 @default.
• W2100044668 date "2015-01-01" @default.
• W2100044668 modified "2023-10-16" @default.
• W2100044668 title "Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter" @default.
• W2100044668 cites W1518421544 @default.
• W2100044668 cites W1565685526 @default.
• W2100044668 cites W1838246889 @default.
• W2100044668 cites W1866253623 @default.
• W2100044668 cites W1972300380 @default.
• W2100044668 cites W1972418515 @default.
• W2100044668 cites W1972645384 @default.
• W2100044668 cites W1982186232 @default.
• W2100044668 cites W1983619210 @default.
• W2100044668 cites W1988974002 @default.
• W2100044668 cites W2012724887 @default.
• W2100044668 cites W2015970734 @default.
• W2100044668 cites W2020924292 @default.
• W2100044668 cites W2026052194 @default.
• W2100044668 cites W2028539387 @default.
• W2100044668 cites W2029479831 @default.
• W2100044668 cites W2032158286 @default.
• W2100044668 cites W2047733883 @default.
• W2100044668 cites W2058942385 @default.
• W2100044668 cites W2068734132 @default.
• W2100044668 cites W2077112528 @default.
• W2100044668 cites W2092482867 @default.
• W2100044668 cites W2097910973 @default.
• W2100044668 cites W2101795514 @default.
• W2100044668 cites W2102231104 @default.
• W2100044668 cites W2102681112 @default.
• W2100044668 cites W2111928827 @default.
• W2100044668 cites W2114562144 @default.
• W2100044668 cites W2116203390 @default.
• W2100044668 cites W2116308765 @default.
• W2100044668 cites W2119844940 @default.
• W2100044668 cites W2126607534 @default.
• W2100044668 cites W2132629607 @default.
• W2100044668 cites W2133816470 @default.
• W2100044668 cites W2135624157 @default.
• W2100044668 cites W2135838357 @default.
• W2100044668 cites W2143578565 @default.
• W2100044668 cites W2149731471 @default.
• W2100044668 cites W2161360301 @default.
• W2100044668 cites W2167492716 @default.
• W2100044668 doi "https://doi.org/10.1016/j.ijmm.2014.10.004" @default.
• W2100044668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25465160" @default.
• W2100044668 hasPublicationYear "2015" @default.
• W2100044668 type Work @default.
• W2100044668 sameAs 2100044668 @default.
• W2100044668 citedByCount "11" @default.
• W2100044668 countsByYear W21000446682015 @default.
• W2100044668 countsByYear W21000446682016 @default.
• W2100044668 countsByYear W21000446682017 @default.
• W2100044668 countsByYear W21000446682018 @default.
• W2100044668 countsByYear W21000446682019 @default.
• W2100044668 countsByYear W21000446682020 @default.
• W2100044668 countsByYear W21000446682023 @default.
• W2100044668 crossrefType "journal-article" @default.
• W2100044668 hasAuthorship W2100044668A5009914609 @default.
• W2100044668 hasAuthorship W2100044668A5029624579 @default.
• W2100044668 hasAuthorship W2100044668A5045374933 @default.
• W2100044668 hasAuthorship W2100044668A5048707669 @default.
• W2100044668 hasAuthorship W2100044668A5061685613 @default.
• W2100044668 hasAuthorship W2100044668A5070625264 @default.
• W2100044668 hasAuthorship W2100044668A5087600237 @default.
• W2100044668 hasBestOaLocation W21000446682 @default.
• W2100044668 hasConcept C104317684 @default.
• W2100044668 hasConcept C12554922 @default.
• W2100044668 hasConcept C164144092 @default.
• W2100044668 hasConcept C179470777 @default.
• W2100044668 hasConcept C189165786 @default.
• W2100044668 hasConcept C27523624 @default.
• W2100044668 hasConcept C2776925733 @default.
• W2100044668 hasConcept C2779463914 @default.
• W2100044668 hasConcept C2781090273 @default.
• W2100044668 hasConcept C501593827 @default.
• W2100044668 hasConcept C523546767 @default.
• W2100044668 hasConcept C54355233 @default.
• W2100044668 hasConcept C55493867 @default.
• W2100044668 hasConcept C58123911 @default.
• W2100044668 hasConcept C60987743 @default.
• W2100044668 hasConcept C86492073 @default.
• W2100044668 hasConcept C86803240 @default.
• W2100044668 hasConcept C89423630 @default.
• W2100044668 hasConcept C95444343 @default.
• W2100044668 hasConceptScore W2100044668C104317684 @default.
• W2100044668 hasConceptScore W2100044668C12554922 @default.
• W2100044668 hasConceptScore W2100044668C164144092 @default.
• W2100044668 hasConceptScore W2100044668C179470777 @default.
• W2100044668 hasConceptScore W2100044668C189165786 @default.

• next