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- W2100045134 abstract "Abstract Aim Inflammation and fibrosis are present in both colonic diverticulitis and C rohn's disease ( CD ). The molecular pattern of basic fibroblastic growth factor (b FGF ) and syndecan 1 ( SD 1) expression is altered in stenosing CD , but their expression in resected complicated colonic diverticulitis ( ACD ) is unknown. Method The expression of b FGF , SD 1 and tumour necrosis factor α ( TNF ‐α) in 20 patients after resection of ACD was compared with 15 patients having a resection for CD . Analysis was conducted using real‐time reverse transcriptase polymerase chain reaction in biopsy samples. Results Lymphocytic and neutrophil inflammation scores were similar in both groups ( P = 0.771 and P = 0.562). TNF ‐α and b FGF expression was significantly higher in ACD than in CD ( P < 0.0001 and P = 0.009). SD 1 expression was similar in both groups ( P = 0.841). Conclusion TNF ‐α and bFGF are significantly overexpressed in ACD with respect to CD , whilst SD 1 levels do not differ. The findings confirm that inflammation and its association with altered molecular patterns of mucosal healing may play an important role in the phenotype of the diseases." @default.
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- W2100045134 date "2014-02-12" @default.
- W2100045134 modified "2023-09-27" @default.
- W2100045134 title "Expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor α in resected acute colonic diverticulitis" @default.
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- W2100045134 doi "https://doi.org/10.1111/codi.12504" @default.
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