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- W2100045176 startingPage "5206" @default.
- W2100045176 abstract "During regeneration of lamprey spinal axons, growth cones lack filopodia and lamellipodia, contain little actin, and elongate much more slowly than do typical growth cones of embryonic neurons. Moreover, these regenerating growth cones are densely packed with neurofilaments (NFs). Therefore, after spinal hemisection the time course of changes in NF mRNA expression was correlated with the probability of regeneration for each of 18 identified pairs of reticulospinal neurons and 12 cytoarchitectonic groups of spinal projecting neurons. During the first 4 weeks after operation, NF message levels were reduced dramatically in all axotomized reticulospinal neurons, on the basis of semiquantitative in situ hybridization for the single lamprey NF subunit (NF-180). Thereafter, NF expression returned toward normal in neurons whose axons normally regenerate beyond the transection but remained depressed in poorly regenerating neurons. The recovery of NF expression in good regenerators was independent of axon growth across the lesion, because excision of a segment of spinal cord caudal to the transection site blocked regeneration but did not prevent the return of NF-180 mRNA. The early decrease in NF mRNA expression was not accompanied by a reduction in NF protein content. Thus the axotomy-induced loss of most of the axonal volume resulted in a reduced demand for NF rather than a reduction in volume-specific NF synthesis. We conclude that the secondary upregulation of NF message during axonal regeneration in the lamprey CNS may be part of an intrinsic growth program executed only in neurons with a strong propensity for regeneration." @default.
- W2100045176 created "2016-06-24" @default.
- W2100045176 creator A5004597078 @default.
- W2100045176 creator A5014830579 @default.
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- W2100045176 creator A5039223886 @default.
- W2100045176 creator A5043819159 @default.
- W2100045176 creator A5071811541 @default.
- W2100045176 date "1997-07-01" @default.
- W2100045176 modified "2023-10-14" @default.
- W2100045176 title "Recovery of Neurofilament Expression Selectively in Regenerating Reticulospinal Neurons" @default.
- W2100045176 cites W1481475174 @default.
- W2100045176 cites W1504340397 @default.
- W2100045176 cites W1507084031 @default.
- W2100045176 cites W1527110415 @default.
- W2100045176 cites W1537723889 @default.
- W2100045176 cites W1540826223 @default.
- W2100045176 cites W1545010582 @default.
- W2100045176 cites W1547518268 @default.
- W2100045176 cites W1589158534 @default.
- W2100045176 cites W1626927875 @default.
- W2100045176 cites W1802434720 @default.
- W2100045176 cites W1892717557 @default.
- W2100045176 cites W1953469815 @default.
- W2100045176 cites W1962021636 @default.
- W2100045176 cites W1962605561 @default.
- W2100045176 cites W1964895821 @default.
- W2100045176 cites W1965960807 @default.
- W2100045176 cites W1969263895 @default.
- W2100045176 cites W1970264356 @default.
- W2100045176 cites W1971667349 @default.
- W2100045176 cites W1973354555 @default.
- W2100045176 cites W1973538002 @default.
- W2100045176 cites W1976144105 @default.
- W2100045176 cites W1980116218 @default.
- W2100045176 cites W1984509756 @default.
- W2100045176 cites W1985957070 @default.
- W2100045176 cites W1993917117 @default.
- W2100045176 cites W1995288038 @default.
- W2100045176 cites W1996061290 @default.
- W2100045176 cites W1997759612 @default.
- W2100045176 cites W1998769611 @default.
- W2100045176 cites W2000078809 @default.
- W2100045176 cites W2006162209 @default.
- W2100045176 cites W2006939821 @default.
- W2100045176 cites W2007650537 @default.
- W2100045176 cites W2008094802 @default.
- W2100045176 cites W2011345042 @default.
- W2100045176 cites W2017336167 @default.
- W2100045176 cites W2023472494 @default.
- W2100045176 cites W2026539859 @default.
- W2100045176 cites W2027360386 @default.
- W2100045176 cites W2030391972 @default.
- W2100045176 cites W2031662020 @default.
- W2100045176 cites W2032016256 @default.
- W2100045176 cites W2033344414 @default.
- W2100045176 cites W2034685255 @default.
- W2100045176 cites W2034894932 @default.
- W2100045176 cites W2038265658 @default.
- W2100045176 cites W2042754910 @default.
- W2100045176 cites W2046394271 @default.
- W2100045176 cites W2053961518 @default.
- W2100045176 cites W2055563751 @default.
- W2100045176 cites W2058246130 @default.
- W2100045176 cites W2060632930 @default.
- W2100045176 cites W2064315206 @default.
- W2100045176 cites W2065195106 @default.
- W2100045176 cites W2067853204 @default.
- W2100045176 cites W2071689238 @default.
- W2100045176 cites W2072124547 @default.
- W2100045176 cites W2073279016 @default.
- W2100045176 cites W2075049569 @default.
- W2100045176 cites W2078635367 @default.
- W2100045176 cites W2080105440 @default.
- W2100045176 cites W2081916344 @default.
- W2100045176 cites W2082469937 @default.
- W2100045176 cites W2082559694 @default.
- W2100045176 cites W2082834967 @default.
- W2100045176 cites W2089750155 @default.
- W2100045176 cites W2096133068 @default.
- W2100045176 cites W2100661175 @default.
- W2100045176 cites W2122080265 @default.
- W2100045176 cites W2128635872 @default.
- W2100045176 cites W2135390829 @default.
- W2100045176 cites W2135957649 @default.
- W2100045176 cites W2142089813 @default.
- W2100045176 cites W2144852970 @default.
- W2100045176 cites W2156782975 @default.
- W2100045176 cites W2169622416 @default.
- W2100045176 cites W2171602378 @default.
- W2100045176 cites W2272201577 @default.
- W2100045176 cites W298213654 @default.
- W2100045176 cites W4293247451 @default.
- W2100045176 cites W4298413215 @default.
- W2100045176 doi "https://doi.org/10.1523/jneurosci.17-13-05206.1997" @default.
- W2100045176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573315" @default.
- W2100045176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9185558" @default.
- W2100045176 hasPublicationYear "1997" @default.