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- W2100045343 abstract "Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and healthJournal of HepatologyVol. 57Issue 1PreviewUrsodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via mechanisms not yet fully understood. Its adequate biliary enrichment is considered mandatory for therapeutic efficacy. However, precise determination of biliary enrichment of UDCA is not possible in clinical practice. Therefore, we investigated (i) the relationship between biliary enrichment and plasma pharmacokinetics of UDCA, (ii) the effect of UDCA on plasma and biliary bile acid composition and conjugation patterns, and (iii) on the intestinal detoxification machinery in patients with PBC and healthy controls. Full-Text PDF The molar concentrations of five bile acids in duodenal bile were incorrect in Table 2 on page 136 of this article. The correct Table 2 is presented below. The authors apologize for any inconvenience caused.Table 2Molar concentrations (μmol/L) of bile acids in duodenal bile of 11 patients with PBC and 11 healthy subjects (in parentheses) before and after daily intake of 15 mg/kg UDCA during 3 weeks. Data are given as mean ± SD.UDCA, ursodeoxycholic acid; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; LCA, lithocholic acid; G-, glycine conjugate; T-, taurine conjugate. Open table in a new tab UDCA, ursodeoxycholic acid; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; LCA, lithocholic acid; G-, glycine conjugate; T-, taurine conjugate." @default.
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- W2100045343 date "2014-03-01" @default.
- W2100045343 modified "2023-09-28" @default.
- W2100045343 title "Corrigendum to: “Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health” [J Hepatol 2012;57:133–140]" @default.
- W2100045343 doi "https://doi.org/10.1016/j.jhep.2013.11.027" @default.
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