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- W2100046131 abstract "We examined the role of the hyperpolarization-activated current ( I h ) in the generation of the respiratory rhythm using a spontaneously active brainstem slice of mice. This preparation contains the hypoglossus (XII) nucleus, which is activated in-phase with inspiration and the pre-Bötzinger complex (PBC), the presumed site for respiratory rhythm generation. Voltage-clamp recordings ( n = 90) indicate that cesium (Cs) (5 m m ) blocked 77.2% of the I h current, and ZD 7288 (100 μ m ) blocked 85.8% of the I h current. This blockade increased the respiratory frequency by 161% in Cs and by 150% in ZD 7288 and increased the amplitude of integrated population activity in the XII by 97% in Cs and by 162% in ZD 7288, but not in the PBC (Cs, by 19%; ZD 7288, by −4.56%). All inspiratory PBC neurons ( n = 44) recorded in current clamp within the active network revealed a significantly decreased frequency of action potentials during the interburst interval and an earlier onset of inspiratory bursts after I h current blockade. However, hyperpolarizing current pulses evoked only in a small proportion of inspiratory neurons (0% of type I; 29% of type II neurons) a depolarizing sag. Most of the neurons expressing an I h current (86%) were pacemaker neurons, which continued to generate rhythmic bursts after inactivating the respiratory network pharmacologically with CNQX alone or with CNQX, AP-5, strychnine, bicuculline, and carbenoxolone. Cs and ZD 7288 increased the frequency of pacemaker bursts and decreased the frequency of action potentials between pacemaker bursts. Our findings suggest that the I h current plays an important role in modulating respiratory frequency, which is presumably mediated by pacemaker neurons." @default.
- W2100046131 created "2016-06-24" @default.
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- W2100046131 date "2000-04-15" @default.
- W2100046131 modified "2023-10-15" @default.
- W2100046131 title "The Role of the Hyperpolarization-Activated Current in Modulating Rhythmic Activity in the Isolated Respiratory Network of Mice" @default.
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- W2100046131 doi "https://doi.org/10.1523/jneurosci.20-08-02994.2000" @default.
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