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• W2100046341 abstract "Abstract NO is a potent molecule involved in the cytotoxic events mediated by macrophages (MØ) against microorganisms. We reported previously that inhibition of MØ protein tyrosine phosphatases (PTPs) mediates a protective effect against Leishmania infection, which was NO-dependent. Herein, we show that the PTP inhibitors of the peroxovanadium (pV) class, bpV(phen) and bpV(pic), can similarly increase murine MØ IFN-γ-induced NO generation. Using various second messenger (JAK2, MEK, Erk1/Erk2, and p38) antagonists, we found that the Erk1/Erk2 pathway was the principal pathway submitted to regulation by PTPs in the context of IFN-γ-driven MØ activation and increase in NO production. We observed that bpV(phen) increases inducible NO synthase (iNOS) expression, resulting in enhanced NO production, whereas the bpV(pic) increase of NO production does not seem to result from a modulation of iNOS expression. Transcription factors STAT-1α and NF-κB, recognized for their importance in NO generation, were not affected by the pV treatment. However, AP-1 was strongly activated by bpV(phen) but not by bpV(pic). Collectively, our results suggest that increased IFN-γ-induced NO production, observed after bpV(phen) treatment, involves the activation of the transcription factor AP-1 by Erk1/Erk2- and stress-activated protein kinase/JNK-dependent transduction mechanisms." @default.
• W2100046341 created "2016-06-24" @default.
• W2100046341 creator A5003294144 @default.
• W2100046341 creator A5031662171 @default.
• W2100046341 creator A5072923919 @default.
• W2100046341 date "2006-12-14" @default.
• W2100046341 modified "2023-10-04" @default.
• W2100046341 title "Role of protein tyrosine phosphatases in the regulation of interferon-γ-induced macrophage nitric oxide generation: implication of ERK pathway and AP-1 activation" @default.
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• W2100046341 doi "https://doi.org/10.1189/jlb.0505252" @default.
• W2100046341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17170076" @default.
• W2100046341 hasPublicationYear "2006" @default.
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