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• W2100046421 abstract "The telomerase ribonucleoprotein reverse transcriptase uses its RNA subunit as a template to synthesize telomeric repeats and maintain telomere tracts on chromosome ends. In the ciliate Euplotes crassus, the core telomerase ribonucleoprotein particle undergoes a developmentally programmed assembly into three higher order complexes after mating. Here, we provide evidence using oligonucleotide-directed affinity purification that all of the E.crassus telomerase complexes contain at least two enzyme active sites. Furthermore, we show using co-immunoprecipitation experiments that EcTERT, the telomerase catalytic subunit, undergoes multimerization in vitro. Two independent interaction domains were identified in EcTERT, one at the N-terminus that spans amino acids 186-354 and one at the C-terminus that spans amino acids 755-857. Unexpectedly, we found that TERT can form head-to-head, tail-to-tail and head-to-tail oligomers in vitro, implying that E.crassus telomerase has the potential to assume different conformations in vivo. Together, these data indicate that oligomerization is a conserved feature of telomerase and that the minimal functional unit of the enzyme is a dimer." @default.
• W2100046421 created "2016-06-24" @default.
• W2100046421 creator A5021240054 @default.
• W2100046421 creator A5033979709 @default.
• W2100046421 creator A5050613147 @default.
• W2100046421 date "2002-09-15" @default.
• W2100046421 modified "2023-09-23" @default.
• W2100046421 title "Oligomerization of the telomerase reverse transcriptase from Euplotes crassus" @default.
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• W2100046421 doi "https://doi.org/10.1093/nar/gkf513" @default.
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