FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100046799> ?p ?o ?g. }

• W2100046799 abstract "The go-to cognitive enhancers of today are those that are widely available rather than optimal for the user, including drugs typically prescribed for treatment of ADHD (e.g., methylphenidate) and sleep disturbances such as narcolepsy (modafinil). While highly effective in their intended therapeutic role, performance gains in healthy populations are modest at best and profoundly inconsistent across subgroups and individuals. We propose a method for in silico screening of possible novel cognitive enhancers followed by high-throughput in vivo and in vitro validation. The proposed method uses gene expression data to evaluate the the collection of activated or suppressed signaling pathways in tissues or neurons of the cognitively enhanced brain. An algorithm maps expression data onto signaling pathways and quantifies their individual activation strength. The collective pathways and their activation form what we term the signaling pathway cloud, a biological fingerprint of cognitive enhancement (or any other condition of interest). Drugs can then be screened and ranked based on their ability to minimize, mimic, or exaggerate pathway activation or suppression within that cloud. Using this approach, one may predict the efficacy of many drugs that may enhance various aspects of cognition before costly preclinical studies and clinical trials are undertaken." @default.
• W2100046799 created "2016-06-24" @default.
• W2100046799 creator A5008472454 @default.
• W2100046799 creator A5013472071 @default.
• W2100046799 creator A5036742375 @default.
• W2100046799 creator A5053045436 @default.
• W2100046799 date "2015-02-06" @default.
• W2100046799 modified "2023-10-16" @default.
• W2100046799 title "Screening and personalizing nootropic drugs and cognitive modulator regimens in silico" @default.
• W2100046799 cites W1883695122 @default.
• W2100046799 cites W1963588721 @default.
• W2100046799 cites W1964247625 @default.
• W2100046799 cites W1978643681 @default.
• W2100046799 cites W1980778878 @default.
• W2100046799 cites W1981972440 @default.
• W2100046799 cites W1986105672 @default.
• W2100046799 cites W1986603538 @default.
• W2100046799 cites W1988112454 @default.
• W2100046799 cites W1988512056 @default.
• W2100046799 cites W1988893294 @default.
• W2100046799 cites W1992261094 @default.
• W2100046799 cites W2006914006 @default.
• W2100046799 cites W2007581462 @default.
• W2100046799 cites W2010213938 @default.
• W2100046799 cites W2035085103 @default.
• W2100046799 cites W2037221301 @default.
• W2100046799 cites W2041016916 @default.
• W2100046799 cites W2047979193 @default.
• W2100046799 cites W2073330852 @default.
• W2100046799 cites W2073452891 @default.
• W2100046799 cites W2075654334 @default.
• W2100046799 cites W2086936470 @default.
• W2100046799 cites W2096158640 @default.
• W2100046799 cites W2099499796 @default.
• W2100046799 cites W2106095767 @default.
• W2100046799 cites W2106645858 @default.
• W2100046799 cites W2110892837 @default.
• W2100046799 cites W2119815552 @default.
• W2100046799 cites W2121261256 @default.
• W2100046799 cites W2123713110 @default.
• W2100046799 cites W2132042075 @default.
• W2100046799 cites W2133468657 @default.
• W2100046799 cites W2137874618 @default.
• W2100046799 cites W2142742274 @default.
• W2100046799 cites W2146458042 @default.
• W2100046799 cites W2149107469 @default.
• W2100046799 cites W2151129911 @default.
• W2100046799 cites W2167057573 @default.
• W2100046799 doi "https://doi.org/10.3389/fnsys.2015.00004" @default.
• W2100046799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4319391" @default.
• W2100046799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25705179" @default.
• W2100046799 hasPublicationYear "2015" @default.
• W2100046799 type Work @default.
• W2100046799 sameAs 2100046799 @default.
• W2100046799 citedByCount "8" @default.
• W2100046799 countsByYear W21000467992015 @default.
• W2100046799 countsByYear W21000467992016 @default.
• W2100046799 countsByYear W21000467992017 @default.
• W2100046799 countsByYear W21000467992018 @default.
• W2100046799 countsByYear W21000467992019 @default.
• W2100046799 countsByYear W21000467992020 @default.
• W2100046799 crossrefType "journal-article" @default.
• W2100046799 hasAuthorship W2100046799A5008472454 @default.
• W2100046799 hasAuthorship W2100046799A5013472071 @default.
• W2100046799 hasAuthorship W2100046799A5036742375 @default.
• W2100046799 hasAuthorship W2100046799A5053045436 @default.
• W2100046799 hasBestOaLocation W21000467991 @default.
• W2100046799 hasConcept C104317684 @default.
• W2100046799 hasConcept C15744967 @default.
• W2100046799 hasConcept C169760540 @default.
• W2100046799 hasConcept C169900460 @default.
• W2100046799 hasConcept C2775905019 @default.
• W2100046799 hasConcept C2776239663 @default.
• W2100046799 hasConcept C2779494582 @default.
• W2100046799 hasConcept C2780714222 @default.
• W2100046799 hasConcept C55493867 @default.
• W2100046799 hasConcept C60644358 @default.
• W2100046799 hasConcept C70721500 @default.
• W2100046799 hasConcept C71924100 @default.
• W2100046799 hasConcept C86803240 @default.
• W2100046799 hasConcept C98274493 @default.
• W2100046799 hasConceptScore W2100046799C104317684 @default.
• W2100046799 hasConceptScore W2100046799C15744967 @default.
• W2100046799 hasConceptScore W2100046799C169760540 @default.
• W2100046799 hasConceptScore W2100046799C169900460 @default.
• W2100046799 hasConceptScore W2100046799C2775905019 @default.
• W2100046799 hasConceptScore W2100046799C2776239663 @default.
• W2100046799 hasConceptScore W2100046799C2779494582 @default.
• W2100046799 hasConceptScore W2100046799C2780714222 @default.
• W2100046799 hasConceptScore W2100046799C55493867 @default.
• W2100046799 hasConceptScore W2100046799C60644358 @default.
• W2100046799 hasConceptScore W2100046799C70721500 @default.
• W2100046799 hasConceptScore W2100046799C71924100 @default.
• W2100046799 hasConceptScore W2100046799C86803240 @default.
• W2100046799 hasConceptScore W2100046799C98274493 @default.
• W2100046799 hasLocation W21000467991 @default.
• W2100046799 hasLocation W21000467992 @default.
• W2100046799 hasLocation W21000467993 @default.
• W2100046799 hasLocation W21000467994 @default.
• W2100046799 hasOpenAccess W2100046799 @default.

• next