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- W2100047229 abstract "Results:Larynxdosimetric sparingwassignificantwithMonacoplanning(Dmean:X=49.9Gy, M=41.9Gy,p=0.001;V50Gy: X=49.7%,M=26.5%,p=0.034).MonacoderivedplansdeliveredasignificantreductioninacuteGrade3dysphagiainweeks5 (X=52.2%,M=18.8%,p=0.035),6(X=78.3%,M=27.8%,p=0.001)and7(X=100%,M=50%,p=0.001).Nosignificant differencewas witnessed in weeks 1 - 4. Baselineweight loss was comparable at treatment completion (X = -5.2%, M = -5.7%, p = 0.983). Monaco derived plans delivered significant weight gain at 2 month (X = -9.5%, M = -6.4%, p= 0.049), 4 month (X = -12.7%, M = -5.8%, p= 0.027) and 6 month (X = -14.8%, M = +0.5%, p= 0.013) follow-up. Conclusions: Treatment induced acute dysphagia may negatively impact quality of life post head and neck irradiation. Adequate nutritional support during treatment can facilitate good weight management. When nutritional support is reduced post radiotherapy, together with persisting dysphagia, weight management can be impaired. This correlative study highlights the potential importance of the swallowing mechanism on patient health, and how the utilization of biological based planning can facilitate improved midline organ sparing with reduction in resultant toxicities aiding weight management post treatment for improved patient outcomes." @default.
- W2100047229 created "2016-06-24" @default.
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- W2100047229 date "2011-10-01" @default.
- W2100047229 modified "2023-09-26" @default.
- W2100047229 title "IMRT for Oropharyngeal Carcinoma: Improving Acute Dysphagia and Post Treatment Weight Management through Superior Midline Sparing During Definitive Chemo-Radiation" @default.
- W2100047229 doi "https://doi.org/10.1016/j.ijrobp.2011.06.801" @default.
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