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- W2100048174 abstract "The hemodynamic and antianginal effects of the organic nitrates are greatly reduced during therapy designed to provide 24-hour protection throughout each day. Although the mechanisms of tolerance are not clearly understood, it is likely that tolerance is related to a combination of reduced sulfhydryl groups in vascular smooth muscle and neurohormonal activation. These changes would reduce nitrate-induced vasodilation and induce sodium and water retention with an increase in plasma volume. These reflex neurohormonal changes would reduce the hemodynamic effect of any given degree of nitrate-induced vasodilation. Although preliminary studies suggest that diuretic therapy or the use of converting enzyme inhibitors may reduce or abolish tolerance, further clinical studies are required to confirm these findings." @default.
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- W2100048174 date "1992-09-01" @default.
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- W2100048174 title "Neurohormonal activation during nitrate therapy: A possible mechanism for tolerance" @default.
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- W2100048174 doi "https://doi.org/10.1016/0002-9149(92)90600-4" @default.
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