FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100049822> ?p ?o ?g. }

• W2100049822 endingPage "1698" @default.
• W2100049822 startingPage "1685" @default.
• W2100049822 abstract "G protein-coupled receptor 39 (GPR39) is a constitutively active, orphan member of the ghrelin receptor family that is activated by zinc ions. GPR39 is here described to be expressed in a full-length, biologically active seven-transmembrane form, GPR39-1a, as well as in a truncated splice variant five-transmembrane form, GPR39-1b. The 3' exon of the GPR39 gene overlaps with an antisense gene called LYPD1 (Ly-6/PLAUR domain containing 1). Quantitative RT-PCR analysis demonstrated that GPR39-1a is expressed selectively throughout the gastrointestinal tract, including the liver and pancreas as well as in the kidney and adipose tissue, whereas the truncated GPR39-1b form has a more broad expression pattern, including the central nervous system but with highest expression in the stomach and small intestine. In contrast, the LYPD1 antisense gene is highly expressed throughout the central nervous system as characterized with both quantitative RT-PCR and in situ hybridization analysis. A functional analysis of the GPR39 promoter region identified sites for the hepatocyte nuclear factors 1alpha and 4alpha (HNF-1alpha and -4alpha) and specificity protein 1 (SP1) transcription factors as being important for the expression of GPR39. In vivo experiments in rats demonstrated that GPR39 is up-regulated in adipose tissue during fasting and in response to streptozotocin treatment, although its expression is kept constant in the liver from the same animals. GPR39-1a was expressed in white but not brown adipose tissue and was down-regulated during adipocyte differentiation of fibroblasts. It is concluded that the transcriptional control mechanism, the tissue expression pattern, and in vivo response to physiological stimuli all indicate that the GPR39 receptor very likely is of importance for the function of a number of metabolic organs, including the liver, gastrointestinal tract, pancreas, and adipose tissue." @default.
• W2100049822 created "2016-06-24" @default.
• W2100049822 creator A5006871697 @default.
• W2100049822 creator A5011163375 @default.
• W2100049822 creator A5015951201 @default.
• W2100049822 creator A5021396103 @default.
• W2100049822 creator A5027979965 @default.
• W2100049822 creator A5077494149 @default.
• W2100049822 creator A5082647986 @default.
• W2100049822 date "2007-07-01" @default.
• W2100049822 modified "2023-10-18" @default.
• W2100049822 title "GPR39 Splice Variants Versus Antisense Gene LYPD1: Expression and Regulation in Gastrointestinal Tract, Endocrine Pancreas, Liver, and White Adipose Tissue" @default.
• W2100049822 cites W1970938572 @default.
• W2100049822 cites W1977591111 @default.
• W2100049822 cites W1980405692 @default.
• W2100049822 cites W1995734405 @default.
• W2100049822 cites W1998591058 @default.
• W2100049822 cites W2002514583 @default.
• W2100049822 cites W2007576186 @default.
• W2100049822 cites W2010695917 @default.
• W2100049822 cites W2022832486 @default.
• W2100049822 cites W2026726511 @default.
• W2100049822 cites W2028010103 @default.
• W2100049822 cites W2036861042 @default.
• W2100049822 cites W2037328290 @default.
• W2100049822 cites W2042434832 @default.
• W2100049822 cites W2046161078 @default.
• W2100049822 cites W2046402357 @default.
• W2100049822 cites W2047258533 @default.
• W2100049822 cites W2051410725 @default.
• W2100049822 cites W2070849419 @default.
• W2100049822 cites W2082642928 @default.
• W2100049822 cites W2088234544 @default.
• W2100049822 cites W2090697491 @default.
• W2100049822 cites W2100729071 @default.
• W2100049822 cites W2112085129 @default.
• W2100049822 cites W2114422744 @default.
• W2100049822 cites W2117008929 @default.
• W2100049822 cites W2132603015 @default.
• W2100049822 cites W2139025111 @default.
• W2100049822 cites W2145028950 @default.
• W2100049822 cites W2145157621 @default.
• W2100049822 cites W2150707944 @default.
• W2100049822 cites W2153619533 @default.
• W2100049822 cites W2158156090 @default.
• W2100049822 cites W2160197941 @default.
• W2100049822 cites W2160570394 @default.
• W2100049822 cites W2162839806 @default.
• W2100049822 cites W2163456630 @default.
• W2100049822 cites W2163865122 @default.
• W2100049822 cites W2172251828 @default.
• W2100049822 doi "https://doi.org/10.1210/me.2007-0055" @default.
• W2100049822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17488974" @default.
• W2100049822 hasPublicationYear "2007" @default.
• W2100049822 type Work @default.
• W2100049822 sameAs 2100049822 @default.
• W2100049822 citedByCount "76" @default.
• W2100049822 countsByYear W21000498222012 @default.
• W2100049822 countsByYear W21000498222013 @default.
• W2100049822 countsByYear W21000498222014 @default.
• W2100049822 countsByYear W21000498222015 @default.
• W2100049822 countsByYear W21000498222017 @default.
• W2100049822 countsByYear W21000498222018 @default.
• W2100049822 countsByYear W21000498222019 @default.
• W2100049822 countsByYear W21000498222020 @default.
• W2100049822 countsByYear W21000498222021 @default.
• W2100049822 countsByYear W21000498222022 @default.
• W2100049822 countsByYear W21000498222023 @default.
• W2100049822 crossrefType "journal-article" @default.
• W2100049822 hasAuthorship W2100049822A5006871697 @default.
• W2100049822 hasAuthorship W2100049822A5011163375 @default.
• W2100049822 hasAuthorship W2100049822A5015951201 @default.
• W2100049822 hasAuthorship W2100049822A5021396103 @default.
• W2100049822 hasAuthorship W2100049822A5027979965 @default.
• W2100049822 hasAuthorship W2100049822A5077494149 @default.
• W2100049822 hasAuthorship W2100049822A5082647986 @default.
• W2100049822 hasBestOaLocation W21000498221 @default.
• W2100049822 hasConcept C104317684 @default.
• W2100049822 hasConcept C134018914 @default.
• W2100049822 hasConcept C150194340 @default.
• W2100049822 hasConcept C151955695 @default.
• W2100049822 hasConcept C153911025 @default.
• W2100049822 hasConcept C171089720 @default.
• W2100049822 hasConcept C2778764654 @default.
• W2100049822 hasConcept C2780512811 @default.
• W2100049822 hasConcept C54355233 @default.
• W2100049822 hasConcept C55493867 @default.
• W2100049822 hasConcept C86803240 @default.
• W2100049822 hasConceptScore W2100049822C104317684 @default.
• W2100049822 hasConceptScore W2100049822C134018914 @default.
• W2100049822 hasConceptScore W2100049822C150194340 @default.
• W2100049822 hasConceptScore W2100049822C151955695 @default.
• W2100049822 hasConceptScore W2100049822C153911025 @default.
• W2100049822 hasConceptScore W2100049822C171089720 @default.
• W2100049822 hasConceptScore W2100049822C2778764654 @default.
• W2100049822 hasConceptScore W2100049822C2780512811 @default.
• W2100049822 hasConceptScore W2100049822C54355233 @default.
• W2100049822 hasConceptScore W2100049822C55493867 @default.

• next