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• W2100050025 abstract "Abstract Lung transplantation remains the only effective therapy for patients with end-stage pulmonary diseases. Unfortunately, acute rejection of the lung remains a frequent complication and is an important cause of morbidity and mortality. The induction of transplant tolerance is thought to be dependent, in part, on the balance between allograft effector mechanisms mediated by effector T lymphocytes (Teff), and regulatory mechanisms mediated by FOXP3+ regulatory T cells (Treg). In this study, we explored an approach to tip the balance in favor of regulatory mechanisms by modulating chemokine activity. We demonstrate in an adoptive transfer model of lung rejection that CXCR3-deficient CD8+ Teff have impaired migration into the lungs compared with wild-type Teff, which results in a dramatic reduction in fatal pulmonary inflammation. The lungs of surviving mice contained tolerized CXCR3-deficient Teff, as well as a large increase in Treg. We confirmed that Treg were needed for tolerance and that their ability to induce tolerance was dependent on their numbers in the lung relative to the numbers of Teff. These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8+ Teff into the target organ and suggest a novel approach to achieve transplant tolerance." @default.
• W2100050025 created "2016-06-24" @default.
• W2100050025 creator A5008009598 @default.
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• W2100050025 creator A5055995920 @default.
• W2100050025 creator A5062073102 @default.
• W2100050025 creator A5076007225 @default.
• W2100050025 date "2011-06-15" @default.
• W2100050025 modified "2023-10-12" @default.
• W2100050025 title "Inhibiting CXCR3-Dependent CD8+ T Cell Trafficking Enhances Tolerance Induction in a Mouse Model of Lung Rejection" @default.
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• W2100050025 doi "https://doi.org/10.4049/jimmunol.1001049" @default.
• W2100050025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3859457" @default.
• W2100050025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21555535" @default.
• W2100050025 hasPublicationYear "2011" @default.
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