Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100050327> ?p ?o ?g. }
- W2100050327 endingPage "6216" @default.
- W2100050327 startingPage "6216" @default.
- W2100050327 abstract "Nucleoside-derived drugs play an important role in the treatment of cancer. Here, we present the synthesis and characterization of an intriguing series of N3 conjugated Re(CO)3 thymidine complexes. The complexes were characterized by NMR spectroscopy and mass spectrometry and their cytotoxicity was assessed against A549 cells. A similar dependence on the spacer length and the toxicity has been found for N3 functionalized complexes as recently reported for their C5′ counterparts. A remarkable cytotoxic complex 22, carrying a dodecylene spacer at position N3 with a bis-quinoline metal chelate moiety, with an IC50 value of 3.4 ± 1.6 μM, has been identified. Addition of a 100-fold excess of thymidine did not statistically reduce the observed cytotoxicity of all complexes. Cellular uptake studies of complex 22 have been performed by fluorescent microscopy, showing that compound 22 was clearly internalized into A549 cells. Temperature dependent uptake studies, blocking experiments with thymidine, and endosomal co-localization suggest that uptake of 22 occurs via passive diffusion and endocytosis." @default.
- W2100050327 created "2016-06-24" @default.
- W2100050327 creator A5005151282 @default.
- W2100050327 creator A5010432339 @default.
- W2100050327 creator A5016671170 @default.
- W2100050327 creator A5019900484 @default.
- W2100050327 creator A5050169826 @default.
- W2100050327 creator A5076995372 @default.
- W2100050327 creator A5079714111 @default.
- W2100050327 date "2011-01-01" @default.
- W2100050327 modified "2023-09-25" @default.
- W2100050327 title "Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes" @default.
- W2100050327 cites W1548955637 @default.
- W2100050327 cites W1941750302 @default.
- W2100050327 cites W1963779075 @default.
- W2100050327 cites W1964689733 @default.
- W2100050327 cites W1972185917 @default.
- W2100050327 cites W1979621373 @default.
- W2100050327 cites W1982046216 @default.
- W2100050327 cites W1989270330 @default.
- W2100050327 cites W1991249120 @default.
- W2100050327 cites W1997112174 @default.
- W2100050327 cites W2008453146 @default.
- W2100050327 cites W2011855362 @default.
- W2100050327 cites W2016956375 @default.
- W2100050327 cites W2019235036 @default.
- W2100050327 cites W2021527389 @default.
- W2100050327 cites W2024734755 @default.
- W2100050327 cites W2028977508 @default.
- W2100050327 cites W2034032951 @default.
- W2100050327 cites W2038411698 @default.
- W2100050327 cites W2040802176 @default.
- W2100050327 cites W2043550097 @default.
- W2100050327 cites W2048122078 @default.
- W2100050327 cites W2055286653 @default.
- W2100050327 cites W2058288585 @default.
- W2100050327 cites W2064929404 @default.
- W2100050327 cites W2065615680 @default.
- W2100050327 cites W2069850423 @default.
- W2100050327 cites W2071393559 @default.
- W2100050327 cites W2085665681 @default.
- W2100050327 cites W2094813554 @default.
- W2100050327 cites W2109465342 @default.
- W2100050327 cites W2125592780 @default.
- W2100050327 cites W2132355991 @default.
- W2100050327 cites W2155208683 @default.
- W2100050327 cites W2161979278 @default.
- W2100050327 cites W2162213228 @default.
- W2100050327 cites W2163215727 @default.
- W2100050327 doi "https://doi.org/10.1039/c0dt01452d" @default.
- W2100050327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21369609" @default.
- W2100050327 hasPublicationYear "2011" @default.
- W2100050327 type Work @default.
- W2100050327 sameAs 2100050327 @default.
- W2100050327 citedByCount "36" @default.
- W2100050327 countsByYear W21000503272012 @default.
- W2100050327 countsByYear W21000503272013 @default.
- W2100050327 countsByYear W21000503272014 @default.
- W2100050327 countsByYear W21000503272015 @default.
- W2100050327 countsByYear W21000503272016 @default.
- W2100050327 countsByYear W21000503272017 @default.
- W2100050327 countsByYear W21000503272018 @default.
- W2100050327 countsByYear W21000503272019 @default.
- W2100050327 countsByYear W21000503272020 @default.
- W2100050327 countsByYear W21000503272021 @default.
- W2100050327 countsByYear W21000503272022 @default.
- W2100050327 crossrefType "journal-article" @default.
- W2100050327 hasAuthorship W2100050327A5005151282 @default.
- W2100050327 hasAuthorship W2100050327A5010432339 @default.
- W2100050327 hasAuthorship W2100050327A5016671170 @default.
- W2100050327 hasAuthorship W2100050327A5019900484 @default.
- W2100050327 hasAuthorship W2100050327A5050169826 @default.
- W2100050327 hasAuthorship W2100050327A5076995372 @default.
- W2100050327 hasAuthorship W2100050327A5079714111 @default.
- W2100050327 hasConcept C109316439 @default.
- W2100050327 hasConcept C112613896 @default.
- W2100050327 hasConcept C12554922 @default.
- W2100050327 hasConcept C178790620 @default.
- W2100050327 hasConcept C185592680 @default.
- W2100050327 hasConcept C202751555 @default.
- W2100050327 hasConcept C2776543447 @default.
- W2100050327 hasConcept C2776568683 @default.
- W2100050327 hasConcept C2777108182 @default.
- W2100050327 hasConcept C521977710 @default.
- W2100050327 hasConcept C55493867 @default.
- W2100050327 hasConcept C66974803 @default.
- W2100050327 hasConcept C71240020 @default.
- W2100050327 hasConcept C81729549 @default.
- W2100050327 hasConcept C86803240 @default.
- W2100050327 hasConceptScore W2100050327C109316439 @default.
- W2100050327 hasConceptScore W2100050327C112613896 @default.
- W2100050327 hasConceptScore W2100050327C12554922 @default.
- W2100050327 hasConceptScore W2100050327C178790620 @default.
- W2100050327 hasConceptScore W2100050327C185592680 @default.
- W2100050327 hasConceptScore W2100050327C202751555 @default.
- W2100050327 hasConceptScore W2100050327C2776543447 @default.
- W2100050327 hasConceptScore W2100050327C2776568683 @default.
- W2100050327 hasConceptScore W2100050327C2777108182 @default.