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- W2100052852 abstract "This chapter investigates the biosynthesis of queuosine and the occurrence of Q or G at position 34 in transfer RNA (tRNA)Asn, tRNAAsp, tRNAHis, and tRNATyr from eubacteria and from eukaryotes to elucidate the biological significance of queuine and the Q-family of tRNAs. Queuosine appears to be synthesized de novo only in eubacteria. Guanosine-5'-triphosphate (GTP) serves as a precursor from which finally 7-aminomethyl-7-deazaguanine is formed. This part of the biosynthetic pathway requires iron, possibly a heme iron protein. In the next steps the Escherichia coli (E. coli) tRNA transglycosylase exchanges guanine 34 by 7-aminomethyl-7-deazaguanine and the cyclopentendiol moiety is attached to the precursor at the level of tRNA. The epoxide-derivative oQ is an intermediate in the biosynthesis of Q. The epoxide, being formed when E. coli or Salmonella typhimurium are grown in glucose salt medium, is converted to Q after a shift to enriched media. Lower and higher eukaryotes, except yeast, are supplied with queuine by bacterial sources. The presence of G34 in place of Q in cytosolic and chloroplast tRNAs of tobacco and wheat leaves is caused by the absence of queuine. In contrast to leaves, wheat germ contains high amounts of queuine." @default.
- W2100052852 created "2016-06-24" @default.
- W2100052852 creator A5028023244 @default.
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- W2100052852 date "1990-01-01" @default.
- W2100052852 modified "2023-09-26" @default.
- W2100052852 title "Chapter 2 Biosynthesis and Function of Queuine and Queuosine tRNAs" @default.
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- W2100052852 doi "https://doi.org/10.1016/s0301-4770(08)61488-8" @default.
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