FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100052979> ?p ?o ?g. }

• W2100052979 endingPage "1924" @default.
• W2100052979 startingPage "1913" @default.
• W2100052979 abstract "Within the basal ganglia, the subthalamic nucleus (STN) is the only glutamatergic structure and occupies a central position in the indirect pathway. In rat, the STN receives serotonergic input from the dorsal raphe nucleus and expresses serotonergic receptors.This study examined the consequences of serotonergic neurotransmission modulation on STN neuron activity.In vivo single-unit extracellular recordings, HPLC determination, and rotarod and bar test were performed in control, 4-chloro-DL-phenylalanine methyl ester hydrochloride- (pCPA, a serotonin synthesis inhibitor) and chronically fluoxetine-treated rats.The pCPA treatment and the administration of serotonin (5-HT) receptor antagonists increased number of bursting neurons in the STN. The systemic administration of the 5-HT(1A) agonist, 8-OH-DPAT, decreased the firing rate and increased the coefficient of variation of STN neurons in pCPA-treated rats but not in control animals. Additionally, microinjection of 8-OH-DPAT into the STN reduced the firing rate of STN neurons, while microinjection of the 5-HT(2C) agonist, Ro 60-0175, increased the firing rate in both control and fluoxetine-treated animals. Finally, the fluoxetine challenge increased the firing rate of STN neurons in fluoxetine-treated rats and induced catalepsy.Our results indicate that the depletion and the blockage of 5-HT modify STN neuron firing pattern. STN neuron activity is under the control of 5-HT(1A) and 5-HT(2C) receptors located both inside and outside the STN. Finally, fluoxetine increases STN neuron activity in chronically fluoxetine-treated rats, which may explain the role of this nucleus in fluoxetine-induced extrapyramidal side effects." @default.
• W2100052979 created "2016-06-24" @default.
• W2100052979 creator A5000561694 @default.
• W2100052979 creator A5017896316 @default.
• W2100052979 creator A5040313321 @default.
• W2100052979 creator A5047109978 @default.
• W2100052979 creator A5054743025 @default.
• W2100052979 creator A5062853175 @default.
• W2100052979 creator A5080584521 @default.
• W2100052979 creator A5089463822 @default.
• W2100052979 date "2013-11-24" @default.
• W2100052979 modified "2023-10-16" @default.
• W2100052979 title "Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration" @default.
• W2100052979 cites W1508156824 @default.
• W2100052979 cites W1513720278 @default.
• W2100052979 cites W1533742544 @default.
• W2100052979 cites W1968177231 @default.
• W2100052979 cites W1968320440 @default.
• W2100052979 cites W1970083936 @default.
• W2100052979 cites W1978525638 @default.
• W2100052979 cites W1979059699 @default.
• W2100052979 cites W1979332775 @default.
• W2100052979 cites W1981358082 @default.
• W2100052979 cites W1981616104 @default.
• W2100052979 cites W1982554457 @default.
• W2100052979 cites W1985256582 @default.
• W2100052979 cites W1987448986 @default.
• W2100052979 cites W1989324985 @default.
• W2100052979 cites W1989715374 @default.
• W2100052979 cites W1994702289 @default.
• W2100052979 cites W1996673522 @default.
• W2100052979 cites W2000226181 @default.
• W2100052979 cites W2002970043 @default.
• W2100052979 cites W2006818658 @default.
• W2100052979 cites W2010391271 @default.
• W2100052979 cites W2011524007 @default.
• W2100052979 cites W2012884927 @default.
• W2100052979 cites W2013453689 @default.
• W2100052979 cites W2014001501 @default.
• W2100052979 cites W2014837790 @default.
• W2100052979 cites W2015387012 @default.
• W2100052979 cites W2016929551 @default.
• W2100052979 cites W2016983964 @default.
• W2100052979 cites W2020060414 @default.
• W2100052979 cites W2030404790 @default.
• W2100052979 cites W2035632600 @default.
• W2100052979 cites W2043809060 @default.
• W2100052979 cites W2046188669 @default.
• W2100052979 cites W2047575016 @default.
• W2100052979 cites W2048750487 @default.
• W2100052979 cites W2049044813 @default.
• W2100052979 cites W2053074524 @default.
• W2100052979 cites W2055244807 @default.
• W2100052979 cites W2058544402 @default.
• W2100052979 cites W2059250402 @default.
• W2100052979 cites W2061515934 @default.
• W2100052979 cites W2069819750 @default.
• W2100052979 cites W2073630554 @default.
• W2100052979 cites W2075566185 @default.
• W2100052979 cites W2076285845 @default.
• W2100052979 cites W2078061001 @default.
• W2100052979 cites W2079238331 @default.
• W2100052979 cites W2095453856 @default.
• W2100052979 cites W2099652807 @default.
• W2100052979 cites W2099902873 @default.
• W2100052979 cites W2117635724 @default.
• W2100052979 cites W2127838460 @default.
• W2100052979 cites W2151019735 @default.
• W2100052979 cites W4239438238 @default.
• W2100052979 doi "https://doi.org/10.1007/s00213-013-3333-0" @default.
• W2100052979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3984421" @default.
• W2100052979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24271033" @default.
• W2100052979 hasPublicationYear "2013" @default.
• W2100052979 type Work @default.
• W2100052979 sameAs 2100052979 @default.
• W2100052979 citedByCount "21" @default.
• W2100052979 countsByYear W21000529792014 @default.
• W2100052979 countsByYear W21000529792015 @default.
• W2100052979 countsByYear W21000529792016 @default.
• W2100052979 countsByYear W21000529792017 @default.
• W2100052979 countsByYear W21000529792018 @default.
• W2100052979 countsByYear W21000529792019 @default.
• W2100052979 countsByYear W21000529792020 @default.
• W2100052979 countsByYear W21000529792021 @default.
• W2100052979 countsByYear W21000529792022 @default.
• W2100052979 countsByYear W21000529792023 @default.
• W2100052979 crossrefType "journal-article" @default.
• W2100052979 hasAuthorship W2100052979A5000561694 @default.
• W2100052979 hasAuthorship W2100052979A5017896316 @default.
• W2100052979 hasAuthorship W2100052979A5040313321 @default.
• W2100052979 hasAuthorship W2100052979A5047109978 @default.
• W2100052979 hasAuthorship W2100052979A5054743025 @default.
• W2100052979 hasAuthorship W2100052979A5062853175 @default.
• W2100052979 hasAuthorship W2100052979A5080584521 @default.
• W2100052979 hasAuthorship W2100052979A5089463822 @default.
• W2100052979 hasBestOaLocation W21000529791 @default.
• W2100052979 hasConcept C126322002 @default.
• W2100052979 hasConcept C134018914 @default.

• next