Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100053857> ?p ?o ?g. }
- W2100053857 endingPage "2645" @default.
- W2100053857 startingPage "2637" @default.
- W2100053857 abstract "Blood levels of 25-hydroxyvitamin D [25(OH)D] is the generally accepted indicator of vitamin D status, but no universal reference level has been reached.The objective of the study was to determine the threshold at which low plasma 25(OH)D levels are associated with fractures in elderly men and clarify the importance of low levels on total fracture burden.In the Uppsala Longitudinal Study of Adult Men, a population-based cohort (mean age, 71 yr, n = 1194), we examined the relationship between 25(OH)D and risk for fracture. Plasma 25(OH)D levels were measured with high-pressure liquid chromatography-mass spectrometry.The study was conducted in the municipality of Uppsala in Sweden, a country with a high fracture incidence.Time to fracture was measured.During follow-up (median 11 yr), 309 of the participants (26%) sustained a fracture. 25(OH)D levels below 40 nmol/liter, which corresponded to the fifth percentile of 25(OH)D, were associated with a modestly increased risk for fracture, multivariable-adjusted hazard ratio 1.65 (95% confidence interval 1.09-2.49). No risk difference was detected above this level. Approximately 3% of the fractures were attributable to low 25(OH)D levels in this population.Vitamin D insufficiency is not a major cause of fractures in community-dwelling elderly men in Sweden. Despite the fact that cutaneous synthesis of previtamin D during the winter season is undetectable at this northern latitude of 60 degrees, only one in 20 had 25(OH)D levels below 40 nmol/liter, the threshold at which the risk for fracture started to increase. Genetic adaptations to limited UV light may be an explanation for our findings." @default.
- W2100053857 created "2016-06-24" @default.
- W2100053857 creator A5013083863 @default.
- W2100053857 creator A5027035779 @default.
- W2100053857 creator A5044523693 @default.
- W2100053857 creator A5050841187 @default.
- W2100053857 creator A5056393181 @default.
- W2100053857 creator A5057108575 @default.
- W2100053857 creator A5059801770 @default.
- W2100053857 creator A5062057544 @default.
- W2100053857 creator A5082190944 @default.
- W2100053857 creator A5084401784 @default.
- W2100053857 creator A5088574660 @default.
- W2100053857 date "2010-06-01" @default.
- W2100053857 modified "2023-10-10" @default.
- W2100053857 title "Plasma 25-Hydroxyvitamin D Levels and Fracture Risk in a Community-Based Cohort of Elderly Men in Sweden" @default.
- W2100053857 cites W1942646560 @default.
- W2100053857 cites W1956824670 @default.
- W2100053857 cites W1968675377 @default.
- W2100053857 cites W1971783341 @default.
- W2100053857 cites W1982405195 @default.
- W2100053857 cites W1982824674 @default.
- W2100053857 cites W1985448630 @default.
- W2100053857 cites W1992826431 @default.
- W2100053857 cites W1994496611 @default.
- W2100053857 cites W2000249938 @default.
- W2100053857 cites W2009719437 @default.
- W2100053857 cites W2013097711 @default.
- W2100053857 cites W2023423578 @default.
- W2100053857 cites W2037977509 @default.
- W2100053857 cites W2050196352 @default.
- W2100053857 cites W2071853414 @default.
- W2100053857 cites W2081485841 @default.
- W2100053857 cites W2102463350 @default.
- W2100053857 cites W2109159740 @default.
- W2100053857 cites W2118540989 @default.
- W2100053857 cites W2124139470 @default.
- W2100053857 cites W2133817813 @default.
- W2100053857 cites W2136476728 @default.
- W2100053857 cites W2137416195 @default.
- W2100053857 cites W2151353276 @default.
- W2100053857 cites W2156592711 @default.
- W2100053857 cites W2167973547 @default.
- W2100053857 cites W2168801485 @default.
- W2100053857 cites W2169929115 @default.
- W2100053857 cites W2172203829 @default.
- W2100053857 cites W2322274315 @default.
- W2100053857 doi "https://doi.org/10.1210/jc.2009-2699" @default.
- W2100053857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20332246" @default.
- W2100053857 hasPublicationYear "2010" @default.
- W2100053857 type Work @default.
- W2100053857 sameAs 2100053857 @default.
- W2100053857 citedByCount "93" @default.
- W2100053857 countsByYear W21000538572012 @default.
- W2100053857 countsByYear W21000538572013 @default.
- W2100053857 countsByYear W21000538572014 @default.
- W2100053857 countsByYear W21000538572015 @default.
- W2100053857 countsByYear W21000538572016 @default.
- W2100053857 countsByYear W21000538572017 @default.
- W2100053857 countsByYear W21000538572018 @default.
- W2100053857 countsByYear W21000538572019 @default.
- W2100053857 countsByYear W21000538572020 @default.
- W2100053857 countsByYear W21000538572021 @default.
- W2100053857 countsByYear W21000538572022 @default.
- W2100053857 countsByYear W21000538572023 @default.
- W2100053857 crossrefType "journal-article" @default.
- W2100053857 hasAuthorship W2100053857A5013083863 @default.
- W2100053857 hasAuthorship W2100053857A5027035779 @default.
- W2100053857 hasAuthorship W2100053857A5044523693 @default.
- W2100053857 hasAuthorship W2100053857A5050841187 @default.
- W2100053857 hasAuthorship W2100053857A5056393181 @default.
- W2100053857 hasAuthorship W2100053857A5057108575 @default.
- W2100053857 hasAuthorship W2100053857A5059801770 @default.
- W2100053857 hasAuthorship W2100053857A5062057544 @default.
- W2100053857 hasAuthorship W2100053857A5082190944 @default.
- W2100053857 hasAuthorship W2100053857A5084401784 @default.
- W2100053857 hasAuthorship W2100053857A5088574660 @default.
- W2100053857 hasBestOaLocation W21000538571 @default.
- W2100053857 hasConcept C105795698 @default.
- W2100053857 hasConcept C120665830 @default.
- W2100053857 hasConcept C121332964 @default.
- W2100053857 hasConcept C122048520 @default.
- W2100053857 hasConcept C124490489 @default.
- W2100053857 hasConcept C126322002 @default.
- W2100053857 hasConcept C134018914 @default.
- W2100053857 hasConcept C144024400 @default.
- W2100053857 hasConcept C149923435 @default.
- W2100053857 hasConcept C201903717 @default.
- W2100053857 hasConcept C207103383 @default.
- W2100053857 hasConcept C2776541429 @default.
- W2100053857 hasConcept C2778885795 @default.
- W2100053857 hasConcept C2779740938 @default.
- W2100053857 hasConcept C2908647359 @default.
- W2100053857 hasConcept C33923547 @default.
- W2100053857 hasConcept C44249647 @default.
- W2100053857 hasConcept C61511704 @default.
- W2100053857 hasConcept C71924100 @default.
- W2100053857 hasConcept C72563966 @default.