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- W2100056505 abstract "Synapses driven by action potentials are thought to release transmitter in an all-or-none fashion; either one synaptic vesicle undergoes exocytosis, or there is no release. We have estimated the glutamate concentration transient at climbing fiber synapses on Purkinje cells by measuring the inhibition of excitatory postsynaptic currents (EPSCs) produced by a low-affinity competitive antagonist of AMPA receptors, gamma-DGG. The results, together with simulations using a kinetic model of the AMPA receptor, suggest that the peak glutamate concentration at this synapse is dependent on release probability but is not affected by pooling of transmitter released from neighboring synapses. We propose that the mechanism responsible for the elevated glutamate concentration at this synapse is the simultaneous release of multiple vesicles per site." @default.
- W2100056505 created "2016-06-24" @default.
- W2100056505 creator A5012027999 @default.
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- W2100056505 date "2001-10-01" @default.
- W2100056505 modified "2023-09-29" @default.
- W2100056505 title "Multivesicular Release at Climbing Fiber-Purkinje Cell Synapses" @default.
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- W2100056505 doi "https://doi.org/10.1016/s0896-6273(01)00488-3" @default.
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