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- W2100056598 abstract "Abstract Hypochlorous acid (HOCl), a reactive oxygen species (ROS), plays a significant biological role in living systems. However, abnormal levels of HOCl are implicated in many inflammation‐associated diseases. Therefore, the detection of HOCl is of great importance. In this work, we describe the HOCl‐promoted cyclization of rhodamine‐thiosemicarbazides to rhodamine‐oxadiazoles, which is then exploited as a novel design strategy for the development of a new fluorescence turn‐on HOCl probe 2 . On the basis of the fluorescence resonance energy transfer (FRET) signaling mechanism, 2 was further converted into 1 a and 1 b , which represent the first paradigm of FRET‐based ratiometric fluorescent HOCl probes. The outstanding features of 1 a and 1 b include well‐resolved emission peaks, high sensitivity, high selectivity, good functionality at physiological pH, rapid response, low cytotoxicity, and good cell‐membrane permeability. Furthermore, these excellent attributes enable us to demonstrate, for the first time, the ratiometric imaging of endogenously produced HOCl in living cells by using these novel ratiometric probes. We expect that 1 a and 1 b will be useful molecular tools for studies of HOCl biology. In addition, the HOCl‐promoted cyclization reaction of rhodamine‐thiosemicarbazides to rhodamine‐oxadiazoles should be widely applicable for the development of different types of fluorescent HOCl probes." @default.
- W2100056598 created "2016-06-24" @default.
- W2100056598 creator A5005016303 @default.
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- W2100056598 creator A5067483347 @default.
- W2100056598 date "2012-01-23" @default.
- W2100056598 modified "2023-10-18" @default.
- W2100056598 title "Fluorescent Detection of Hypochlorous Acid from Turn-On to FRET-Based Ratiometry by a HOCl-Mediated Cyclization Reaction" @default.
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- W2100056598 doi "https://doi.org/10.1002/chem.201101918" @default.
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