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• W2100056890 abstract "ABSTRACT Earlier studies have revealed that human cytomegalovirus rapidly inhibits the growth of fibroblasts, blocking cell cycle progression at multiple points, including the G 1 -to-S-phase transition. The present study demonstrates that the UL69 protein, a virus-encoded constituent of the virion, is able to arrest cell cycle progression when introduced into uninfected cells. Expression of the UL69 protein causes U2 OS cells and primary human fibroblasts to accumulate within the G 1 compartment of the cell cycle, and serum fails to induce the progression of quiescent human fibroblasts into the S phase when the protein is present. Therefore, the UL69 protein is at least partially responsible for the cell cycle block that is instituted after infection of permissive cells with human cytomegalovirus." @default.
• W2100056890 created "2016-06-24" @default.
• W2100056890 creator A5000668079 @default.
• W2100056890 creator A5052096519 @default.
• W2100056890 date "1999-01-01" @default.
• W2100056890 modified "2023-09-26" @default.
• W2100056890 title "Human Cytomegalovirus UL69 Protein Induces Cells To Accumulate in G ₁ Phase of the Cell Cycle" @default.
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• W2100056890 doi "https://doi.org/10.1128/jvi.73.1.676-683.1999" @default.
• W2100056890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/103874" @default.
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