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- W2100057436 abstract "Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in trans on opposing cells. In the developing nervous system, the Eph-ephrin signaling system controls a large variety of cellular responses including contact-mediated attraction or repulsion, adhesion or de-adhesion, and migration. Eph-ephrin signaling can be bidirectional, and is subject to modulation by ectodomain cleavage of ephrins and by Eph-ephrin endocytosis. Recent work has highlighted the importance of higher-order clustering of functional Eph-ephrin complexes and the requirement for Rho GTPases as signal transducers. Co-expression of Ephs and ephrins within the same cellular membrane can result in Eph-ephrin cis interaction or in lateral segregation into distinct domains from where they signal opposing effects on the axon." @default.
- W2100057436 created "2016-06-24" @default.
- W2100057436 creator A5063529902 @default.
- W2100057436 creator A5080798848 @default.
- W2100057436 date "2007-05-01" @default.
- W2100057436 modified "2023-10-16" @default.
- W2100057436 title "Bidirectional Eph–ephrin signaling during axon guidance" @default.
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- W2100057436 doi "https://doi.org/10.1016/j.tcb.2007.03.004" @default.
- W2100057436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17420126" @default.
- W2100057436 hasPublicationYear "2007" @default.
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