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• W2100057652 endingPage "3185" @default.
• W2100057652 startingPage "3173" @default.
• W2100057652 abstract "Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the formation of organs that depend on inductive interactions between epithelial and mesenchymal tissues. In previous tissue recombination experiments with normal and Lef1(-/-) tooth germs, we found that the effect of LEF1 expression in the epithelium is tissue nonautonomous and transferred to the subjacent mesenchyme. Here we examine the molecular basis for LEF1 function and find that the epithelium of the developmentally arrested Lef1(-/-) tooth rudiments fails to express Fgf4, Shh, and Bmp4, but not Wnt10a. We identify the Fgf4 gene as a direct transcriptional target for LEF1 and show that beads soaked with recombinant FGF4 protein can fully overcome the developmental arrest of Lef1(-/-) tooth germs. In addition, we find that FGF4 beads induce rapidly the expression of Fgf3 in dental mesenchyme and that both epithelial and mesenchymal FGF proteins induce the delayed expression of Shh in the epithelium. Taken together, these data indicate that a single target of LEF1 can account for the function of LEF1 in tooth development and for a relay of a Wnt signal reception to a cascade of FGF signaling activities, allowing for a sequential and reciprocal communication between epithelium and mesenchyme." @default.
• W2100057652 created "2016-06-24" @default.
• W2100057652 creator A5005123748 @default.
• W2100057652 creator A5022682784 @default.
• W2100057652 creator A5028791272 @default.
• W2100057652 creator A5056079502 @default.
• W2100057652 creator A5083891200 @default.
• W2100057652 date "2002-12-15" @default.
• W2100057652 modified "2023-10-17" @default.
• W2100057652 title "FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in <i>Lef1^−/−</i> mice" @default.
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• W2100057652 doi "https://doi.org/10.1101/gad.1035602" @default.
• W2100057652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/187508" @default.
• W2100057652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12502739" @default.
• W2100057652 hasPublicationYear "2002" @default.
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