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- W2100059370 abstract "In view of their permeability to small peptides, it has been postulated that human erythrocytes may play a role in terminating the action of some circulating peptide hormones. Work using classical paper chromatographic techniques for detecting free amino acids indicated that the octapeptide, des-(Arg9)-bradykinin, enters these cells and its amino-terminal arginine residue is released by cytosolic aminopeptidase-P. We have used 1H NMR to monitor directly the release of arginine from bradykinin. The hydrolytic reaction rate in hemolysates, with an initial peptide concentration of 13.0 mmol l−1 was 6.5 mmol (1 packed red cell)−1h−1. But no reaction was evident after a 4.5-h incubation with intact cells, thus contradicting the earlier suggestion that erythrocytes are involved in the primary inactivation of this hormone. This is consistent with our previous findings that the pentapeptide leu-enkephalin fails to enter human erythrocytes but that its lower-order degradation products may do so." @default.
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- W2100059370 date "1987-06-01" @default.
- W2100059370 modified "2023-10-14" @default.
- W2100059370 title "No evidence for bradykinin hydrolysis in human erythrocyte suspensions: H NMR studies" @default.
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- W2100059370 doi "https://doi.org/10.1002/ajh.2830250208" @default.
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