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- W2100060480 abstract "Summary Th e objective of this study was to investigate the eff ects of undernutrition during late gestation on plasma concentration of insulin-like growth factor (IGF1), leptin, insulin and glucose in pregnant and lactating ewes. Ten twin-bearing shropshire ewes were fed either adequately (AN; 100% energy and protein requirements) or restrictedly (RN; about 60% of energy and protein requirements) fed during the last six weeks of gestation. Ewe’s blood samples were taken at 50, 28 and 10 days pre-partum as well as at lambing and 7, 17 and 35 days post-partum. At lambing plasma glucose concentrations sharply increased in both groups and it was signifi cantly lower in RN ewes in comparison with AN ewes. Plasma concentrations of insulin and leptin were not aff ected by late gestational undernutrition. Plasma IGF1 concentrations in RN ewes (78 ±8 ng/ml) was signifi cantly lower (P<0.05) than that in AN ewes (110 ±8 ng/ml). Plasma IGF1 decreased in RN ewes during late gestation and then increased sharply at lambing and during fi rst month of lactation. In contrast IGF1 concentration was relatively constant both pre and postnataly in AN ewes. IGF1 values in restricted fed ewes were signifi cantly lower than values in adequately fed ewes during gestation. Surprisingly IGF1 plasma in RN ewes was signifi cantly lower at 35 days (110 vs. 164 ng/ml) post-partum in comparison with those in AN ewes. In conclusion, results showed late gestational undernutrion causes a decrease in plasma glucose and IGF1 at parturition as well as during late gestation. In addition, late gestational undernutrition seems to have longer term eff ect on plasma IGF1 even when ewes are adequately fed during lactation." @default.
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- W2100060480 date "2011-01-12" @default.
- W2100060480 modified "2023-09-26" @default.
- W2100060480 title "Late Gestational Undernutrition Alters Plasma IGF-1 Concentration During Subsequent Lactation in Ewe" @default.
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