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- W2100061696 abstract "Using computational tools we explored the impact of local synaptic inhibition on the plasticity of excitatory synapses in dendrites. The latter critically depends on the intracellular concentration of calcium, which in turn, depends on membrane potential and thus on inhibitory activity in particular dendritic compartments. We systematically characterized the dependence of excitatory synaptic plasticity on dendritic morphology, loci and strength, as well as on the spatial distribution of inhibitory synapses and on the level of excitatory activity. Plasticity of excitatory synapses may attain three states: “protected” (unchanged), potentiated (LTP) or depressed (LTD). The transition between these three plasticity states could be finely tuned by synaptic inhibition with high spatial resolution. Strategic placement of inhibition could give rise to the co-existence of all three states over short dendritic branches. We compared the plasticity effect of the innervation patterns typical to different inhibitory subclasses – Chandelier, basket, Martinotti and double bouquet – in a detailed model of a layer 5 pyramidal cell. Our study suggests that dendritic inhibition plays a key role in shaping and fine-tuning excitatory synaptic plasticity in dendrites." @default.
- W2100061696 created "2016-06-24" @default.
- W2100061696 creator A5013964408 @default.
- W2100061696 creator A5025022011 @default.
- W2100061696 creator A5037833688 @default.
- W2100061696 date "2013-01-01" @default.
- W2100061696 modified "2023-10-16" @default.
- W2100061696 title "The role of dendritic inhibition in shaping the plasticity of excitatory synapses" @default.
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- W2100061696 doi "https://doi.org/10.3389/fncir.2012.00118" @default.
- W2100061696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3615258" @default.
- W2100061696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23565076" @default.
- W2100061696 hasPublicationYear "2013" @default.
- W2100061696 type Work @default.